UniProt P53965
Tyrosine-protein phosphatase SIW14 (P53965)
Tyrosine-protein phosphatase SIW14 (UniProt P53965), EC 3.1.3.48: 3 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P53965
- Protein
- Tyrosine-protein phosphatase SIW14
- EC
- 3.1.3.48
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 21 · 1 record with a druggable one
Structures
4 records of P53965 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6BYF | Crystal structure of the core catalytic domain of pp-ip phosphatase SIW14 from S. cerevisiae in… | x-ray diffraction | A, B, C, D, E, F, G, H, I | CL | — |
| 6E3B | STRUCTURE OF Siw14 CATALYTIC CORE | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V, W, X, Y | SO4 | 20 (best 0.90) |
| 6E3B | Structure of SIW14 catalytic core | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V, W, X, Y | SO4 | — |
| P53965 | AlphaFold monomer V2.0 prediction for inositol phosphatase SIW14 (P53965) | predicted | A | — | 1 (best 0.43) |
Ligands
Experiment against prediction
- 6BYF chain F against the predicted model P53965: TM-score 0.99, RMSD 0.43 Å
- 6BYF chain C against the predicted model P53965: TM-score 0.99, RMSD 0.60 Å
- 6BYF chain B against the predicted model P53965: TM-score 0.99, RMSD 0.63 Å
- 6BYF chain G against the predicted model P53965: TM-score 0.99, RMSD 0.76 Å
- 6BYF chain A against the predicted model P53965: TM-score 0.98, RMSD 0.87 Å
- 6E3B chain A against the predicted model P53965: TM-score 0.97, RMSD 1.25 Å
- 6E3B chain A against the predicted model P53965: TM-score 0.97, RMSD 1.25 Å
- 6E3B chain T against the predicted model P53965: TM-score 0.97, RMSD 1.37 Å
- 6E3B chain T against the predicted model P53965: TM-score 0.97, RMSD 1.37 Å
Elsewhere
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