UniProt P53550
m7GpppN-mRNA hydrolase (P53550)
m7GpppN-mRNA hydrolase (UniProt P53550), EC 3.6.1.62: 10 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P53550
- Protein
- m7GpppN-mRNA hydrolase
- EC
- 3.6.1.62
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 7 · 1 record with a druggable one
Structures
11 records of P53550 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2JVB | Solution Structure of Catalytic Domain of yDcp2 | solution nmr | A | — | — |
| 2JVB | Solution structure of catalytic domain of YDCP2 | solution nmr | A | — | — |
| 4K6E | Crystal structure of Saccharomyces cerevisiae Dcp2 Nudix domain in complex with Mg | x-ray diffraction | A | — | — |
| 4K6E | Crystal structure of saccharomyces cerevisiae DCP2 nudix domain in complex with mg | x-ray diffraction | A | — | — |
| 4KG3 | Crystal structure of Saccharomyces cerevisiae Dcp2 Nudix domain in complex with Mg (E153Q mutation) | x-ray diffraction | A, B, C | — | — |
| 4KG3 | Crystal structure of saccharomyces cerevisiae DCP2 nudix domain in complex with mg (E153Q mutation) | x-ray diffraction | A, B, C | — | — |
| 4KG4 | Crystal structure of Saccharomyces cerevisiae Dcp2 Nudix domain (E198Q mutation) | x-ray diffraction | A, B | — | — |
| 4KG4 | Crystal structure of saccharomyces cerevisiae DCP2 nudix domain (E198Q mutation) | x-ray diffraction | A, B | — | — |
| 6Y3Z | Crystal structure of the Pby1 ATP-grasp enzyme bound to the S. cerevisiae mRNA decapping complex… | x-ray diffraction | A | MG | 7 (best 0.79) |
| 6Y3Z | Crystal structure of the PBY1 ATP-grasp enzyme bound to the S. cerevisiae mRNA decapping complex… | x-ray diffraction | A | MG | — |
| P53550 | AlphaFold monomer V2.0 prediction for M7GPPPN-mRNA hydrolase (P53550) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 2 records
Experiment against prediction
- 4KG3 chain A against the predicted model P53550: TM-score 0.99, RMSD 0.48 Å
- 4KG3 chain A against the predicted model P53550: TM-score 0.99, RMSD 0.48 Å
- 4KG3 chain C against the predicted model P53550: TM-score 0.98, RMSD 0.78 Å
- 4KG3 chain C against the predicted model P53550: TM-score 0.98, RMSD 0.78 Å
- 4K6E chain A against the predicted model P53550: TM-score 0.98, RMSD 0.78 Å
- 4K6E chain A against the predicted model P53550: TM-score 0.98, RMSD 0.78 Å
- 4KG3 chain B against the predicted model P53550: TM-score 0.98, RMSD 0.84 Å
- 4KG3 chain B against the predicted model P53550: TM-score 0.98, RMSD 0.84 Å
- 4KG4 chain A against the predicted model P53550: TM-score 0.97, RMSD 0.77 Å
- 4KG4 chain A against the predicted model P53550: TM-score 0.97, RMSD 0.77 Å
Elsewhere
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