UniProt P53368
7,8-dihydro-8-oxoguanine triphosphatase (P53368)
7,8-dihydro-8-oxoguanine triphosphatase (UniProt P53368), EC 3.6.1.55, 3.6.1.56: 6 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 6 pockets. Binding sites, druggability and experiment against…
- UniProt
- P53368
- Protein
- 7,8-dihydro-8-oxoguanine triphosphatase
- EC
- 3.6.1.55, 3.6.1.56
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 6 · 1 record with a druggable one
Structures
7 records of P53368 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5MZE | Crystal structure of mouse MTH1 with 8-oxo-dGTP | x-ray diffraction | A, B, C, D | CU, 8DG | — |
| 5MZE | Crystal structure of mouse MTH1 with 8-oxo-dgtp | x-ray diffraction | A, B, C, D | CU, 8DG | — |
| 5MZG | Crystal structure of mouse MTH1 in complex with TH588 | x-ray diffraction | A, B | 2GE, SO4, SCN | — |
| 5MZG | Crystal structure of mouse MTH1 in complex with TH588 | x-ray diffraction | A, B | 2GE, SO4, SCN | — |
| 6EHH | Crystal structure of mouse MTH1 mutant L116M with inhibitor TH588 | x-ray diffraction | A, B, C, D | 2GE, NO3, CU, MG | 6 (best 0.83) |
| 6EHH | Crystal structure of mouse MTH1 mutant L116M with inhibitor TH588 | x-ray diffraction | A, B, C, D | 2GE, NO3, CU, MG | — |
| P53368 | AlphaFold monomer V2.0 prediction for 7,8-dihydro-8-oxoguanine triphosphatase (P53368) | predicted | A | — | — |
Ligands
- 2GE · N~4~-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine · in 4 records
- CU · Copper (II) ion · in 4 records
- 8DG · 8-oxo-2'-deoxyguanosine-5'-triphosphate · in 2 records
- MG · Magnesium ion · in 2 records
- NO3 · Nitrate ion · in 2 records
- SCN · Thiocyanate ion · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 5MZE chain D against the predicted model P53368: TM-score 0.99, RMSD 0.40 Å
- 5MZE chain D against the predicted model P53368: TM-score 0.99, RMSD 0.40 Å
- 5MZE chain C against the predicted model P53368: TM-score 0.99, RMSD 0.41 Å
- 5MZE chain C against the predicted model P53368: TM-score 0.99, RMSD 0.41 Å
- 6EHH chain B against the predicted model P53368: TM-score 0.99, RMSD 0.45 Å
- 6EHH chain B against the predicted model P53368: TM-score 0.99, RMSD 0.45 Å
- 6EHH chain C against the predicted model P53368: TM-score 0.99, RMSD 0.46 Å
- 6EHH chain C against the predicted model P53368: TM-score 0.99, RMSD 0.46 Å
- 6EHH chain D against the predicted model P53368: TM-score 0.99, RMSD 0.49 Å
- 6EHH chain D against the predicted model P53368: TM-score 0.99, RMSD 0.49 Å
Elsewhere
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