UniProt P51977
Retinal dehydrogenase 1 (P51977)
Retinal dehydrogenase 1 (UniProt P51977), EC 1.2.1.36: 7 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P51977
- Protein
- Retinal dehydrogenase 1
- EC
- 1.2.1.36
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 20 · 1 record with a druggable one
Structures
8 records of P51977 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BXS | Sheep liver class 1 aldehyde dehydrogenase with NAD bound | x-ray diffraction | A, B, C, D | — | — |
| 1BXS | Sheep liver class 1 aldehyde dehydrogenase with NAD bound | x-ray diffraction | A, B, C, D | — | — |
| 5ABM | Sheep aldehyde dehydrogenase 1A1 | x-ray diffraction | A, B, C, D | — | — |
| 5AC0 | ovis aries Aldehyde Dehydrogenase 1A1 in complex with a duocarmycin analog | x-ray diffraction | A, B | — | — |
| 5AC0 | Ovis aries aldehyde dehydrogenase 1A1 in complex with a duocarmycin analog | x-ray diffraction | A, B | — | — |
| 5AC1 | Sheep aldehyde dehydrogenase 1A1 with duocarmycin analog inhibitor | x-ray diffraction | A, B, C, D | K9P, TXE, MG | 20 (best 0.85) |
| 5AC1 | Sheep aldehyde dehydrogenase 1A1 with duocarmycin analog inhibitor | x-ray diffraction | A, B, C, D | — | — |
| P51977 | AlphaFold monomer V2.0 prediction for retinal dehydrogenase 1 (P51977) | predicted | A | — | — |
Ligands
- K9P · 1-[(1S)-1-methyl-5-oxidanyl-1,2-dihydrobenzo[e]indol-3-yl]hexan-1-one · in 1 record
- MG · Magnesium ion · in 1 record
- TXE · [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate · in 1 record
Experiment against prediction
- 5AC0 chain B against the predicted model P51977: TM-score 1.00, RMSD 0.39 Å
- 5AC0 chain B against the predicted model P51977: TM-score 1.00, RMSD 0.39 Å
- 5AC0 chain A against the predicted model P51977: TM-score 1.00, RMSD 0.40 Å
- 5AC0 chain A against the predicted model P51977: TM-score 1.00, RMSD 0.40 Å
- 5ABM chain C against the predicted model P51977: TM-score 1.00, RMSD 0.40 Å
- 5ABM chain B against the predicted model P51977: TM-score 1.00, RMSD 0.40 Å
- 5AC1 chain C against the predicted model P51977: TM-score 1.00, RMSD 0.40 Å
- 5AC1 chain C against the predicted model P51977: TM-score 1.00, RMSD 0.40 Å
- 5AC1 chain A against the predicted model P51977: TM-score 1.00, RMSD 0.41 Å
- 5AC1 chain A against the predicted model P51977: TM-score 1.00, RMSD 0.41 Å
Elsewhere
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