UniProt P51813
Cytoplasmic tyrosine-protein kinase BMX (P51813)
Cytoplasmic tyrosine-protein kinase BMX (UniProt P51813), EC 2.7.10.2: 11 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P51813
- Protein
- Cytoplasmic tyrosine-protein kinase BMX
- EC
- 2.7.10.2
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 12 · 2 records with a druggable one
Structures
12 records of P51813 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2EKX | Solution structure of the human BMX SH2 domain | solution nmr | A | — | — |
| 2EKX | Solution structure of the human bmx SH2 domain | solution nmr | A | — | — |
| 2YS2 | Solution structure of the BTK motif of human Cytoplasmic tyrosine-protein kinase BMX | solution nmr | A | — | — |
| 2YS2 | Solution structure of the btk motif of human cytoplasmic tyrosine- protein kinase bmx | solution nmr | A | — | — |
| 3SXR | Crystal structure of BMX non-receptor tyrosine kinase complex with dasatinib | x-ray diffraction | A, B | — | — |
| 3SXR | Crystal structure of bmx non-receptor tyrosine kinase complex with dasatinib | x-ray diffraction | A, B | — | — |
| 3SXS | Crystal structure of BMX non-receptor tyrosine kinase complexed with PP2 | x-ray diffraction | A | — | — |
| 3SXS | Crystal structure of bmx non-receptor tyrosine kinase complexed with PP2 | x-ray diffraction | A | — | — |
| 6I99 | Bone Marrow Tyrosine Kinase in Chromosome X in complex with a newly designed covalent inhibitor JS24 | x-ray diffraction | A, B | H88 | 9 (best 0.66) |
| 6I99 | Bone marrow tyrosine kinase in chromosome X in complex with a newly designed covalent inhibitor JS24 | x-ray diffraction | A, B | H88 | — |
| 8X2A | The Crystal Structure of BMX from Biortus. | x-ray diffraction | A | LTJ, CL | 3 (best 0.58) |
| P51813 | AlphaFold monomer V2.0 prediction for cytoplasmic tyrosine-protein kinase bmx (P51813) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8X2A chain A against the predicted model P51813: TM-score 0.98, RMSD 0.90 Å
- 6I99 chain A against the predicted model P51813: TM-score 0.92, RMSD 1.57 Å
- 6I99 chain A against the predicted model P51813: TM-score 0.92, RMSD 1.57 Å
- 6I99 chain B against the predicted model P51813: TM-score 0.92, RMSD 1.59 Å
- 6I99 chain B against the predicted model P51813: TM-score 0.92, RMSD 1.59 Å
- 3SXS chain A against the predicted model P51813: TM-score 0.91, RMSD 1.68 Å
- 3SXS chain A against the predicted model P51813: TM-score 0.91, RMSD 1.68 Å
- 3SXR chain A against the predicted model P51813: TM-score 0.90, RMSD 1.86 Å
- 3SXR chain A against the predicted model P51813: TM-score 0.90, RMSD 1.86 Å
- 3SXR chain B against the predicted model P51813: TM-score 0.90, RMSD 1.90 Å
Elsewhere
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