UniProt P51788

Chloride channel protein 2 (P51788)

Chloride channel protein 2 (UniProt P51788): 4 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 40 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P51788
Protein: Chloride channel protein 2
Experimental structures: 4
Predicted models: 1
Ligands: 1
Pockets: 40 · 3 records with a druggable one

Structures

5 records of P51788 in the MolNFT archive: 4 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
7XF5	Full length human CLC-2 channel in apo state	electron microscopy	A, B	—	—
8TA3	Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain Apo state with resolved…	electron microscopy	A, B	CL	17 (best 0.83)
8TA4	Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with symmetric C-terminal	electron microscopy	A, B	CL	15 (best 0.89)
8TA6	Cryo-EM structure of the human CLC-2 chloride channel C-terminal domain	electron microscopy	A, B	—	8 (best 0.70)
P51788	AlphaFold monomer V2.0 prediction for chloride channel protein 2 (P51788)	predicted	A	—	—

Ligands

CL · Chloride ion · in 2 records

Experiment against prediction

8TA3 chain A against the predicted model P51788: TM-score 0.96, RMSD 0.96 Å
8TA3 chain B against the predicted model P51788: TM-score 0.95, RMSD 1.06 Å
7XF5 chain B against the predicted model P51788: TM-score 0.95, RMSD 2.21 Å
7XF5 chain A against the predicted model P51788: TM-score 0.94, RMSD 2.51 Å
8TA6 chain B against the predicted model P51788: TM-score 0.91, RMSD 1.48 Å
8TA6 chain A against the predicted model P51788: TM-score 0.90, RMSD 1.78 Å
8TA4 chain A against the predicted model P51788: TM-score 0.83, RMSD 3.97 Å
8TA4 chain B against the predicted model P51788: TM-score 0.83, RMSD 3.75 Å

Elsewhere

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