UniProt P51452
Dual specificity protein phosphatase 3 (P51452)
Dual specificity protein phosphatase 3 (UniProt P51452), EC 3.1.3.16, 3.1.3.48: 12 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 6 pockets. Binding sites, druggability and experiment against…
- UniProt
- P51452
- Protein
- Dual specificity protein phosphatase 3
- EC
- 3.1.3.16, 3.1.3.48
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 6 · 1 record with a druggable one
Structures
13 records of P51452 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1J4X | Human VH1-related dual-specificity phosphatase C124S mutant-peptide complex | x-ray diffraction | A | — | — |
| 1J4X | Human VH1-related dual-specificity phosphatase C124S mutant-peptide complex | x-ray diffraction | A | — | — |
| 1VHR | Human VH1-related dual-specificity phosphatase | x-ray diffraction | A, B | — | — |
| 1VHR | Human VH1-related dual-specificity phosphatase | x-ray diffraction | A, B | — | — |
| 3F81 | Interaction of VHR with SA3 | x-ray diffraction | A, B | — | — |
| 3F81 | Interaction of vhr with SA3 | x-ray diffraction | A, B | — | — |
| 8TK2 | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with… | x-ray diffraction | A, B | I1Y | 3 (best 0.48) |
| 8TK3 | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) having oxidized catalytic cysteine and… | x-ray diffraction | A | I2X | — |
| 8TK4 | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with phosphate | x-ray diffraction | A | PO4 | — |
| 8TK5 | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with HEPES | x-ray diffraction | A, B | — | — |
| 8TK6 | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) in apo form | x-ray diffraction | A, B | — | 3 (best 0.50) |
| 9DJ9 | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) in distinct apo form | x-ray diffraction | A | — | — |
| P51452 | AlphaFold monomer V2.0 prediction for dual specificity protein phosphatase 3 (P51452) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8TK2 chain B against the predicted model P51452: TM-score 0.99, RMSD 0.38 Å
- 1VHR chain B against the predicted model P51452: TM-score 0.99, RMSD 0.50 Å
- 1VHR chain B against the predicted model P51452: TM-score 0.99, RMSD 0.50 Å
- 3F81 chain B against the predicted model P51452: TM-score 0.99, RMSD 0.54 Å
- 3F81 chain B against the predicted model P51452: TM-score 0.99, RMSD 0.54 Å
- 8TK5 chain B against the predicted model P51452: TM-score 0.99, RMSD 0.55 Å
- 8TK4 chain A against the predicted model P51452: TM-score 0.99, RMSD 0.66 Å
- 9DJ9 chain A against the predicted model P51452: TM-score 0.99, RMSD 0.58 Å
- 8TK6 chain B against the predicted model P51452: TM-score 0.99, RMSD 0.63 Å
- 8TK3 chain A against the predicted model P51452: TM-score 0.99, RMSD 0.74 Å
Elsewhere
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