UniProt P50623
SUMO-conjugating enzyme UBC9 (P50623)
SUMO-conjugating enzyme UBC9 (UniProt P50623), EC 2.3.2.-, 6.3.2.-: 12 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 45 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P50623
- Protein
- SUMO-conjugating enzyme UBC9
- EC
- 2.3.2.-, 6.3.2.-, 6.3.2.19
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 45 · 9 records with a druggable one
Structures
13 records of P50623 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2EKE | Structure of a SUMO-binding-motif mimic bound to Smt3p-Ubc9p: conservation of a noncovalent… | x-ray diffraction | A, B | — | 4 (best 0.69) |
| 2EKE | Structure of a sumo-binding-motif mimic bound to SMT3P- UBC9P: conservation of a noncovalent… | x-ray diffraction | A, B | — | 4 (best 0.69) |
| 2GJD | Distinct functional domains of Ubc9 dictate cell survival and resistance to genotoxic stress | x-ray diffraction | A, B, C, D | — | 4 (best 0.78) |
| 2GJD | Distinct functional domains of UBC9 dictate cell survival and resistance to genotoxic stress | x-ray diffraction | A, B, C, D | — | 4 (best 0.78) |
| 3ONG | Crystal structure of UBA2ufd-Ubc9: insights into E1-E2 interactions in Sumo pathways | x-ray diffraction | B, D | — | 3 (best 0.62) |
| 3ONG | Crystal structure of UBA2UFD-UBC9: insights into E1-E2 interactions in sumo pathways | x-ray diffraction | B, D | — | 3 (best 0.62) |
| 5JNE | E2-SUMO-Siz1 E3-SUMO-PCNA complex | x-ray diffraction | B, F | 6LN | 12 (best 0.75) |
| 5JNE | E2-sumo-SIZ1 E3-sumo-PCNA complex | x-ray diffraction | B, F | — | — |
| 6Q83 | Crystal structure of the biportin Pdr6 in complex with UBC9 | x-ray diffraction | B | — | 6 (best 0.76) |
| 6Q83 | Crystal structure of the biportin PDR6 in complex with UBC9 | x-ray diffraction | B | — | — |
| 7P47 | Structure of the E3 ligase Smc5/Nse2 in complex with Ubc9-SUMO thioester mimetic | x-ray diffraction | C | — | 5 (best 0.78) |
| 7P47 | Structure of the E3 ligase SMC5/NSE2 in complex with UBC9-sumo thioester mimetic | x-ray diffraction | C | — | — |
| P50623 | AlphaFold monomer V2.0 prediction for sumo-conjugating enzyme UBC9 (P50623) | predicted | A | — | — |
Ligands
- 6LN · ethane-1,2-dithiol · in 1 record
Experiment against prediction
- 2GJD chain A against the predicted model P50623: TM-score 0.99, RMSD 0.38 Å
- 2GJD chain A against the predicted model P50623: TM-score 0.99, RMSD 0.38 Å
- 2EKE chain A against the predicted model P50623: TM-score 0.99, RMSD 0.45 Å
- 2EKE chain A against the predicted model P50623: TM-score 0.99, RMSD 0.45 Å
- 6Q83 chain B against the predicted model P50623: TM-score 0.98, RMSD 0.78 Å
- 6Q83 chain B against the predicted model P50623: TM-score 0.98, RMSD 0.78 Å
- 2GJD chain B against the predicted model P50623: TM-score 0.98, RMSD 0.84 Å
- 2GJD chain B against the predicted model P50623: TM-score 0.98, RMSD 0.84 Å
- 3ONG chain B against the predicted model P50623: TM-score 0.97, RMSD 0.80 Å
- 3ONG chain B against the predicted model P50623: TM-score 0.97, RMSD 0.80 Å
Elsewhere
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