UniProt P49956
Chromosome transmission fidelity protein 18 (P49956)
Chromosome transmission fidelity protein 18 (UniProt P49956): 16 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 63 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P49956
- Protein
- Chromosome transmission fidelity protein 18
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 63 · 9 records with a druggable one
Structures
17 records of P49956 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5MSM | Structure of the Dcc1-Ctf8-Ctf18C Trimer | x-ray diffraction | C, F | — | 10 (best 0.62) |
| 5MSM | Structure of the DCC1-CTF8-CTF18C trimer | x-ray diffraction | C, F | — | — |
| 5OKC | Crystal structure of the Ctf18-1-8 module from Ctf18-RFC | x-ray diffraction | G, I | NO3 | 5 (best 0.48) |
| 5OKC | Crystal structure of the CTF18-1-8 module from CTF18-rfc | x-ray diffraction | G, I | — | — |
| 5OKI | Crystal structure of the Ctf18-1-8 module from Ctf18-RFC in complex with a 63 kDa fragment of DNA… | x-ray diffraction | E, I | — | 2 (best 0.70) |
| 5OKI | Crystal structure of the CTF18-1-8 module from CTF18-rfc in complex with a 63 kda fragment of DNA… | x-ray diffraction | E, I | — | — |
| 6S1C | P3221 crystal form of the CTF18-1-8/POL2(1-528) complex | x-ray diffraction | D, H | — | — |
| 6S2E | Cryo-EM structure of Ctf18-1-8 in complex with the catalytic domain of DNA polymerase epsilon | electron microscopy | E | — | 4 (best 0.76) |
| 6S2E | Cryo-EM structure of CTF18-1-8 in complex with the catalytic domain of DNA polymerase epsilon | electron microscopy | E | — | — |
| 6S2F | Cryo-EM structure of Ctf18-1-8 in complex with the catalytic domain of DNA polymerase epsilon… | electron microscopy | E | — | 4 (best 0.71) |
| 6S2F | Cryo-EM structure of CTF18-1-8 in complex with the catalytic domain of DNA polymerase epsilon… | electron microscopy | E | — | — |
| 8TW7 | Cryo-EM structure of S. cerevisiae Ctf18-RFC-PCNA complex in Apo state conformation I | electron microscopy | 1 | ADP | 10 (best 0.84) |
| 8TW8 | Cryo-EM structure of S. cerevisiae Ctf18-RFC-PCNA complex in Apo state conformation I | electron microscopy | 1 | ADP | 8 (best 0.88) |
| 8TW9 | Cryo-EM structure of S. cerevisiae PolE-Ctf18-8-1-DNA | electron microscopy | C | — | 6 (best 0.79) |
| 8TWA | Cryo-EM structure of S. cerevisiae Ctf18-RFC-PCNA-PolE-DNA complex | electron microscopy | C, 1 | ADP | 7 (best 0.86) |
| 8TWB | Cryo-EM structure of S. cerevisiae Ctf18-RFC-PCNA-DNA complex | electron microscopy | 1 | ADP | 7 (best 0.88) |
| P49956 | AlphaFold monomer V2.0 prediction for chromosome transmission fidelity protein 18 (P49956) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8TWB chain 1 against the predicted model P49956: TM-score 0.97, RMSD 1.08 Å
- 8TW8 chain 1 against the predicted model P49956: TM-score 0.97, RMSD 1.08 Å
- 8TW7 chain 1 against the predicted model P49956: TM-score 0.97, RMSD 1.08 Å
- 8TWA chain 1 against the predicted model P49956: TM-score 0.60, RMSD 3.99 Å
- 5MSM chain F against the predicted model P49956: TM-score 0.36, RMSD 1.78 Å
- 5MSM chain F against the predicted model P49956: TM-score 0.36, RMSD 1.78 Å
- 5OKC chain G against the predicted model P49956: TM-score 0.35, RMSD 2.47 Å
- 5OKC chain G against the predicted model P49956: TM-score 0.35, RMSD 2.47 Å
- 5OKC chain I against the predicted model P49956: TM-score 0.34, RMSD 2.81 Å
- 5OKC chain I against the predicted model P49956: TM-score 0.34, RMSD 2.81 Å
Elsewhere
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