UniProt P49915
Gmp synthase (P49915)
Gmp synthase (UniProt P49915), EC 6.3.5.2: 4 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 32 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P49915
- Protein
- Gmp synthase
- EC
- 6.3.5.2
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 32 · 2 records with a druggable one
Structures
5 records of P49915 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2VPI | Human GMP synthetase - glutaminase domain | x-ray diffraction | A, B | — | 3 (best 0.37) |
| 2VPI | Human gmp synthetase - glutaminase domain | x-ray diffraction | A, B | — | 3 (best 0.37) |
| 2VXO | Human GMP synthetase in complex with XMP | x-ray diffraction | A, B | XMP, SO4 | 13 (best 0.84) |
| 2VXO | Human gmp synthetase in complex with xmp | x-ray diffraction | A, B | XMP, SO4 | 13 (best 0.84) |
| P49915 | AlphaFold monomer V2.0 prediction for gmp synthase [glutamine- hydrolyzing] (P49915) | predicted | A | — | — |
Ligands
Experiment against prediction
- 2VPI chain A against the predicted model P49915: TM-score 0.97, RMSD 1.13 Å
- 2VPI chain A against the predicted model P49915: TM-score 0.97, RMSD 1.13 Å
- 2VPI chain B against the predicted model P49915: TM-score 0.96, RMSD 1.14 Å
- 2VPI chain B against the predicted model P49915: TM-score 0.96, RMSD 1.14 Å
- 2VXO chain A against the predicted model P49915: TM-score 0.86, RMSD 3.46 Å
- 2VXO chain A against the predicted model P49915: TM-score 0.86, RMSD 3.46 Å
- 2VXO chain B against the predicted model P49915: TM-score 0.84, RMSD 3.82 Å
- 2VXO chain B against the predicted model P49915: TM-score 0.84, RMSD 3.82 Å
Elsewhere
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