UniProt P49642
DNA primase small subunit (P49642)
DNA primase small subunit (UniProt P49642), EC 2.7.7.-, 2.7.7.102: 31 experimental structures on GenesisL1, 7 ligands bound, 9 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P49642
- Protein
- DNA primase small subunit
- EC
- 2.7.7.-, 2.7.7.102
- Experimental structures
- 31
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 9 · 3 records with a druggable one
Structures
31 records of P49642 in the MolNFT archive: 31 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4BPU | Crystal structure of human primase in heterodimeric form, comprising PriS and truncated PriL… | x-ray diffraction | A, C | — | — |
| 4BPU | Crystal structure of human primase in heterodimeric form, comprising pris and truncated pril… | x-ray diffraction | A, C | — | — |
| 4BPW | Crystal structure of human primase bound to UTP | x-ray diffraction | A, C | — | — |
| 4BPW | Crystal structure of human primase bound to UTP | x-ray diffraction | A, C | — | — |
| 4BPX | Crystal structure of human primase in complex with the primase- binding motif of DNA polymerase… | x-ray diffraction | A, C | — | — |
| 4BPX | Crystal structure of human primase in complex with the primase- binding motif of DNA polymerase… | x-ray diffraction | A, C | — | — |
| 4LIK | Crystal structure of the catalytic subunit of human primase | x-ray diffraction | A | — | — |
| 4LIK | Crystal structure of the catalytic subunit of human primase | x-ray diffraction | A | — | — |
| 4LIL | Crystal structure of the catalytic subunit of human primase bound to UTP and Mn | x-ray diffraction | A | — | — |
| 4LIL | Crystal structure of the catalytic subunit of human primase bound to UTP and mn | x-ray diffraction | A | — | — |
| 4MHQ | Crystal structure of human primase catalytic subunit | x-ray diffraction | A | — | — |
| 4MHQ | Crystal structure of human primase catalytic subunit | x-ray diffraction | A | — | — |
| 4RR2 | Crystal structure of human primase | x-ray diffraction | A, C | — | — |
| 4RR2 | Crystal structure of human primase | x-ray diffraction | A, C | — | — |
| 5EXR | Crystal structure of human primosome | x-ray diffraction | A, E | ZN | — |
| 5EXR | Crystal structure of human primosome | x-ray diffraction | A, E | — | — |
| 6R4S | Crystal structure of the PRI1 subunit of human primase bound to ATP | x-ray diffraction | A, E | ZN, MN, ATP | — |
| 6R4T | Crystal structure of the PRI1 subunit of human primase bound to vidarabine triphosphate | x-ray diffraction | A, D | ZN, MN, HEJ | — |
| 6R4U | Crystal structure of the PRI1 subunit of human primase bound to fludarabine triphosphate | x-ray diffraction | A, E | ZN, MN, HFD | — |
| 6R5D | Crystal structure of the PRI1 subunit of human primase bound to datp | x-ray diffraction | A, E | ZN, MN, DTP | — |
| 6R5E | Crystal structure of the PRI1 subunit of human primase bound to 2F-ATP | x-ray diffraction | A, E | ZN, MN, JSQ | — |
| 6RB4 | Crystal structure of the PRI1 subunit of human primase | x-ray diffraction | A | ZN | — |
| 7OPL | Cryoem structure of DNA polymerase alpha - primase bound to SARS cov NSP1 | electron microscopy | C | ZN | — |
| 7U5C | Cryo-EM structure of human CST bound to DNA polymerase alpha-primase in a recruitment state | electron microscopy | A | ZN | 3 (best 0.77) |
| 7U5C | Cryo-EM structure of human cst bound to DNA polymerase alpha-primase in a recruitment state | electron microscopy | A | ZN | — |
| 8D0B | Human cst-DNA polymerase ALPHA/PRIMASE preinitiation complex bound to 4XTEL-foldback template | electron microscopy | D | — | — |
| 8D0K | Human cst-DNA polymerase ALPHA/PRIMASE preinitiation complex bound to 4XTEL-foldback template… | electron microscopy | D | — | — |
| 8D9D | Human DNA polymerase-alpha/primase elongation complex II bound to primer/template | electron microscopy | A | ZN | 3 (best 0.52) |
| 8QJ7 | Cryo-EM structure of human DNA polymerase alpha-primase in pre-initiation stage 1 | electron microscopy | C | ZN, MN, ATP | 3 (best 0.51) |
| 9C8V | Human DNA polymerase alpha/primase - CHAPSO (4 mM) | electron microscopy | A | ZN | — |
| P49642 | AlphaFold monomer V2.0 prediction for DNA primase small subunit (P49642) | — | — | — |
Ligands
- ZN · Zinc ion · in 13 records
- MN · Manganese (II) ion · in 6 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- DTP · 2'-deoxyadenosine 5'-triphosphate · in 1 record
- HEJ · 9-{5-O-[(S)-hydroxy{[(r)-hydroxy(phosphonooxy) phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-9H-purin-6-amine · in 1 record
- HFD · 2-fluoro-9-{5-O-[(R)-hydroxy{[(r)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-9H-purin-6-amine · in 1 record
- JSQ · 2-fluoro-atp · in 1 record
Elsewhere
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