UniProt P49591
Serine--tRNA ligase, cytoplasmic (P49591)
Serine--tRNA ligase, cytoplasmic (UniProt P49591), EC 6.1.1.11: 10 experimental structures and 1 predicted model on GenesisL1, 37 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P49591
- Protein
- Serine--tRNA ligase, cytoplasmic
- EC
- 6.1.1.11
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 37 · 3 records with a druggable one
Structures
11 records of P49591 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3VBB | Crystal Structure of Seryl-tRNA Synthetase from Human at 2.9 angstroms | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3VBB | Crystal structure of seryl-tRNA synthetase from human at 2.9 ångströms | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4L87 | Crystal structure of the human seryl-tRNA synthetase in complex with Ser-SA at 2.9 Angstrom… | x-ray diffraction | A | — | — |
| 4L87 | Crystal structure of the human seryl-tRNA synthetase in complex with ser-sa at 2.9 ångström… | x-ray diffraction | A | — | — |
| 4RQE | human Seryl-tRNA synthetase dimer complexed with two molecules of tRNAsec | x-ray diffraction | A, C | — | — |
| 4RQE | Human seryl-tRNA synthetase dimer complexed with two molecules of trnasec | x-ray diffraction | A, C | — | — |
| 4RQF | human Seryl-tRNA synthetase dimer complexed with one molecule of tRNAsec | x-ray diffraction | A, B | — | — |
| 4RQF | Human seryl-tRNA synthetase dimer complexed with one molecule of trnasec | x-ray diffraction | A, B | — | — |
| 8P7B | CryoEM structure of METTL6 tRNA SerRS complex in a 1:2:2 stoichiometry | electron microscopy | B, D | — | 18 (best 0.75) |
| 8P7C | CryoEM structure of METTL6 tRNA SerRS complex in a 2:2:2 stoichiometry | electron microscopy | B, D | — | 16 (best 0.80) |
| P49591 | AlphaFold monomer V2.0 prediction for serine--tRNA ligase, cytoplasmic (P49591) | predicted | A | — | 3 (best 0.71) |
Experiment against prediction
- 4L87 chain A against the predicted model P49591: TM-score 0.99, RMSD 0.86 Å
- 4L87 chain A against the predicted model P49591: TM-score 0.99, RMSD 0.86 Å
- 4RQE chain C against the predicted model P49591: TM-score 0.98, RMSD 1.16 Å
- 4RQE chain C against the predicted model P49591: TM-score 0.98, RMSD 1.16 Å
- 4RQE chain A against the predicted model P49591: TM-score 0.98, RMSD 1.14 Å
- 4RQE chain A against the predicted model P49591: TM-score 0.98, RMSD 1.14 Å
- 4RQF chain A against the predicted model P49591: TM-score 0.98, RMSD 1.17 Å
- 4RQF chain A against the predicted model P49591: TM-score 0.98, RMSD 1.17 Å
- 4RQF chain B against the predicted model P49591: TM-score 0.97, RMSD 1.55 Å
- 4RQF chain B against the predicted model P49591: TM-score 0.97, RMSD 1.55 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.