UniProt P49281
Natural resistance-associated macrophage protein 2 (P49281)
Natural resistance-associated macrophage protein 2 (UniProt P49281): 8 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 29 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P49281
- Protein
- Natural resistance-associated macrophage protein 2
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 29 · 3 records with a druggable one
Structures
9 records of P49281 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5F0L | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 | x-ray diffraction | D | SO4 | 1 (best 0.35) |
| 5F0L | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 | x-ray diffraction | D | — | — |
| 5F0M | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 (SeMet labeled) | x-ray diffraction | D | — | — |
| 5F0M | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 (semet labeled) | x-ray diffraction | D | — | — |
| 5F0P | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1(L557M) (SeMet labeled) | x-ray diffraction | D | ZN | 1 (best 0.37) |
| 5F0P | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1(L557M) (semet labeled) | x-ray diffraction | D | — | — |
| 9F6N | Human divalent metal transporter 1 (DMT1/SLC11A2) in complex with manganese, in an occluded state | electron microscopy | A | MN | 8 (best 0.51) |
| 9F6O | Human divalent metal transporter 1 (DMT1/SLC11A2) in complex with sybody 1, in an occluded state | electron microscopy | A | — | 9 (best 0.58) |
| P49281 | AlphaFold monomer V2.0 prediction for natural resistance-associated macrophage protein 2 (P49281) | predicted | A | — | 10 (best 0.53) |
Ligands
Experiment against prediction
- 9F6N chain A against the predicted model P49281: TM-score 0.97, RMSD 1.25 Å
- 9F6O chain A against the predicted model P49281: TM-score 0.97, RMSD 1.45 Å
- 5F0L chain D against the predicted model P49281: TM-score 0.46, RMSD 1.51 Å
- 5F0L chain D against the predicted model P49281: TM-score 0.46, RMSD 1.51 Å
- 5F0M chain D against the predicted model P49281: TM-score 0.43, RMSD 1.50 Å
- 5F0M chain D against the predicted model P49281: TM-score 0.43, RMSD 1.50 Å
- 5F0P chain D against the predicted model P49281: TM-score 0.28, RMSD 2.38 Å
- 5F0P chain D against the predicted model P49281: TM-score 0.28, RMSD 2.38 Å
Elsewhere
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