UniProt P49137
MAP kinase-activated protein kinase 2 (P49137)
MAP kinase-activated protein kinase 2 (UniProt P49137), EC 2.7.11.1: 56 experimental structures on GenesisL1, 4 ligands bound, 5 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P49137
- Protein
- MAP kinase-activated protein kinase 2
- EC
- 2.7.11.1
- Experimental structures
- 56
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 5 · 1 record with a druggable one
Structures
56 records of P49137 in the MolNFT archive: 56 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KWP | Crystal Structure of MAPKAP2 | x-ray diffraction | A, B | — | — |
| 1KWP | Crystal structure of MAPKAP2 | x-ray diffraction | A, B | — | — |
| 1NXK | Crystal structure of staurosporine bound to MAP KAP kinase 2 | x-ray diffraction | A, B, C, D | — | — |
| 1NXK | Crystal structure of staurosporine bound to MAP kap kinase 2 | x-ray diffraction | A, B, C, D | — | — |
| 1NY3 | Crystal structure of ADP bound to MAP KAP kinase 2 | x-ray diffraction | A | — | — |
| 1NY3 | Crystal structure of ADP bound to MAP kap kinase 2 | x-ray diffraction | A | — | — |
| 2JBO | Protein kinase MK2 in complex with an inhibitor (crystal form-1, soaking) | x-ray diffraction | A | — | — |
| 2JBO | Protein kinase MK2 in complex with an inhibitor (crystal form-1, soaking) | x-ray diffraction | A | — | — |
| 2JBP | Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization) | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 2JBP | Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization) | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 2OKR | Crystal Structure of the P38a-MAPKAP kinase 2 Heterodimer | x-ray diffraction | C, F | — | — |
| 2OKR | Crystal structure of the P38A-mapkap kinase 2 heterodimer | x-ray diffraction | C, F | — | — |
| 2ONL | Crystal Structure of the p38a-MAPKAP kinase 2 Heterodimer | x-ray diffraction | C, D | — | — |
| 2ONL | Crystal structure of the P38A-mapkap kinase 2 heterodimer | x-ray diffraction | C, D | — | — |
| 2OZA | Structure of p38alpha complex | x-ray diffraction | A | — | — |
| 2OZA | Structure of P38ALPHA complex | x-ray diffraction | A | — | — |
| 2P3G | Crystal structure of a pyrrolopyridine inhibitor bound to MAPKAP Kinase-2 | x-ray diffraction | X | — | — |
| 2P3G | Crystal structure of a pyrrolopyridine inhibitor bound to mapkap kinase-2 | x-ray diffraction | X | — | — |
| 2PZY | Structure of MK2 Complexed with Compound 76 | x-ray diffraction | A, B, C, D | — | — |
| 2PZY | Structure of MK2 complexed with compound 76 | x-ray diffraction | A, B, C, D | — | — |
| 3A2C | Crystal structure of a pyrazolopyrimidine inhibitor complex bound to MAPKAP Kinase-2 (MK2) | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 3A2C | Crystal structure of a pyrazolopyrimidine inhibitor complex bound to mapkap kinase-2 (MK2) | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 3FPM | Crystal Structure of a Squarate Inhibitor bound to MAPKAP Kinase-2 | x-ray diffraction | A | — | — |
| 3FPM | Crystal structure of a squarate inhibitor bound to mapkap kinase-2 | x-ray diffraction | A | — | — |
| 3FYJ | Crystal structure of an optimzied benzothiophene inhibitor bound to MAPKAP Kinase-2 (MK-2) | x-ray diffraction | X | — | — |
| 3FYJ | Crystal structure of an optimzied benzothiophene inhibitor bound to mapkap kinase-2 (mk-2) | x-ray diffraction | X | — | — |
| 3FYK | Crystal structure of a benzthiophene lead bound to MAPKAP Kinase-2 (MK-2) | x-ray diffraction | X | — | — |
| 3FYK | Crystal structure of a benzthiophene lead bound to mapkap kinase-2 (mk-2) | x-ray diffraction | X | — | — |
| 3GOK | Binding site mapping of protein ligands | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 3GOK | Binding site mapping of protein ligands | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 3KA0 | MK2 complex with inhibitor 6-(5-(2-aminopyrimidin-4-ylamino)-2-hydroxyphenyl)-N-methylbenzo[b]thioph… | x-ray diffraction | A | — | — |
| 3KA0 | MK2 complex with inhibitor 6-(5-(2-aminopyrimidin-4-ylamino)-2… | x-ray diffraction | A | — | — |
| 3KC3 | MK2 complexed to inhibitor N4-(7-(benzofuran-2-yl)-1H-indazol-5-yl)pyrimidine-2,4-diamine | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 3KC3 | MK2 complexed to inhibitor N4-(7-(benzofuran-2-yl)-1H-indazol-5-yl) pyrimidine-2,4-diamine | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 3KGA | Crystal structure of MAPKAP kinase 2 (MK2) complexed with a potent 3-aminopyrazole ATP site… | x-ray diffraction | A | — | — |
| 3KGA | Crystal structure of mapkap kinase 2 (MK2) complexed with a potent 3- aminopyrazole ATP site… | x-ray diffraction | A | — | — |
| 3M2W | Crystal structure of MAPKAK kinase 2 (MK2) complexed with a spiroazetidine-tetracyclic ATP site… | x-ray diffraction | A | — | — |
| 3M2W | Crystal structure of mapkak kinase 2 (MK2) complexed with a spiroazetidine-tetracyclic ATP site… | x-ray diffraction | A | — | — |
| 3M42 | Crystal structure of MAPKAP kinase 2 (MK2) complexed with a tetracyclic ATP site inhibitor | x-ray diffraction | A | — | — |
| 3M42 | Crystal structure of mapkap kinase 2 (MK2) complexed with a tetracyclic ATP site inhibitor | x-ray diffraction | A | — | — |
| 3R2B | MK2 kinase bound to Compound 5b | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 3R2B | MK2 kinase bound to compound 5B | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 3R2Y | MK2 kinase bound to Compound 1 | x-ray diffraction | A | — | — |
| 3R2Y | MK2 kinase bound to compound 1 | x-ray diffraction | A | — | — |
| 3R30 | MK2 kinase bound to Compound 2 | x-ray diffraction | A | — | — |
| 3R30 | MK2 kinase bound to compound 2 | x-ray diffraction | A | — | — |
| 3WI6 | Crystal structure of MAPKAP Kinase-2 (MK2) in complex with non-selective inhibitor | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WI6 | Crystal structure of mapkap kinase-2 (MK2) in complex with non- selective inhibitor | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4TYH | Ternary complex of P38 and MK2 with a P38 inhibitor | x-ray diffraction | A | — | — |
| 4TYH | Ternary complex of P38 and MK2 with a P38 inhibitor | x-ray diffraction | A | — | — |
| 6T8X | Crystal structure of MAPKAPK2 (MK2) complexed with pf-3644022 and 5… | x-ray diffraction | A, B, C, D, E, F | B97, CL, MW8 | — |
| 6TCA | Phosphorylated p38 and MAPKAPK2 complex with inhibitor | x-ray diffraction | A, C, E, G | 39G | — |
| 6TCA | Phosphorylated P38 and MAPKAPK2 complex with inhibitor | x-ray diffraction | A, C, E, G | 39G | — |
| 7NRY | Re-refinement of mapkap kinase-2/INHIBITOR complex 3FYJ | x-ray diffraction | X | B97, CL | — |
| 8XX1 | The Crystal Structure of MAPKAP kinase 2 domain from Biortus | x-ray diffraction | A | — | 5 (best 0.61) |
| P49137 | AlphaFold monomer V2.0 prediction for MAP kinase-activated protein kinase 2 (P49137) | — | — | — |
Ligands
- 39G · N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide · in 2 records
- B97 · (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one · in 2 records
- CL · Chloride ion · in 2 records
- MW8 · 5-(4-bromophenyl)-~{N}-(4-piperazin-1-ylphenyl)-~{N}-(pyridin-2-ylmethyl)furan-2-carboxamide · in 1 record
Elsewhere
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