UniProt P48729
Casein kinase I isoform alpha (P48729)
Casein kinase I isoform alpha (UniProt P48729), EC 2.7.11.1: 4 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P48729
- Protein
- Casein kinase I isoform alpha
- EC
- 2.7.11.1
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 1 · 1 record with a druggable one
Structures
5 records of P48729 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5FQD | Structural basis of lenalidomide induced CK1A degradation by the CRL4CRBN ubiquitin ligase | x-ray diffraction | C, F | — | — |
| 6GZD | Crystal structure of Human CSNK1A1 with A86 | x-ray diffraction | A | TCE, LCI | — |
| 6GZD | Crystal structure of human CSNK1A1 with A86 | x-ray diffraction | A | TCE, LCI | — |
| 7WTT | Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A1 (with CK1) | electron microscopy | a | — | — |
| P48729 | AlphaFold monomer V2.0 prediction for casein kinase I isoform alpha (P48729) | predicted | A | — | 1 (best 0.57) |
Ligands
Experiment against prediction
- 5FQD chain C against the predicted model P48729: TM-score 0.99, RMSD 0.70 Å
- 6GZD chain A against the predicted model P48729: TM-score 0.99, RMSD 0.76 Å
- 6GZD chain A against the predicted model P48729: TM-score 0.99, RMSD 0.76 Å
- 7WTT chain a against the predicted model P48729: TM-score 0.98, RMSD 1.00 Å
Elsewhere
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