UniProt P47822
Mediator of RNA polymerase II transcription subunit 21 (P47822)
Mediator of RNA polymerase II transcription subunit 21 (UniProt P47822): 8 experimental structures and 1 predicted model on GenesisL1, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P47822
- Protein
- Mediator of RNA polymerase II transcription subunit 21
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 2 · 2 records with a druggable one
Structures
9 records of P47822 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1YKE | Structure of the mediator MED7/MED21 subcomplex | x-ray diffraction | B, D | — | — |
| 1YKE | Structure of the mediator MED7/MED21 subcomplex | x-ray diffraction | B, D | — | — |
| 1YKH | Structure of the mediator MED7/MED21 (Med7/Srb7) subcomplex | x-ray diffraction | B | — | — |
| 1YKH | Structure of the mediator MED7/MED21 (MED7/SRB7) subcomplex | x-ray diffraction | B | — | — |
| 5OQM | Structure of yeast transcription pre-initiation complex with tfiih and core mediator | electron microscopy | n | — | — |
| 5SVA | Mediator-RNA polymerase II pre-initiation complex | electron microscopy | W | — | — |
| 7UIF | Mediator-PIC Early (Core B) | electron microscopy | u | — | 1 (best 0.85) |
| 7UIO | Mediator-PIC Early (Composite Model) | electron microscopy | Au, Bu | — | 1 (best 0.81) |
| P47822 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 21… | predicted | A | — | — |
Experiment against prediction
- 1YKE chain D against the predicted model P47822: TM-score 0.92, RMSD 1.53 Å
- 1YKE chain D against the predicted model P47822: TM-score 0.92, RMSD 1.53 Å
- 7UIO chain Au against the predicted model P47822: TM-score 0.90, RMSD 1.43 Å
- 7UIO chain Bu against the predicted model P47822: TM-score 0.90, RMSD 1.43 Å
- 7UIF chain u against the predicted model P47822: TM-score 0.90, RMSD 1.44 Å
- 1YKH chain B against the predicted model P47822: TM-score 0.88, RMSD 2.04 Å
- 1YKH chain B against the predicted model P47822: TM-score 0.88, RMSD 2.04 Å
- 1YKE chain B against the predicted model P47822: TM-score 0.87, RMSD 1.76 Å
- 1YKE chain B against the predicted model P47822: TM-score 0.87, RMSD 1.76 Å
- 5SVA chain W against the predicted model P47822: TM-score 0.87, RMSD 1.76 Å
Elsewhere
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