UniProt P46598
Heat shock protein 90 homolog (P46598)
Heat shock protein 90 homolog (UniProt P46598): 11 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P46598
- Protein
- Heat shock protein 90 homolog
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 10 · 4 records with a druggable one
Structures
12 records of P46598 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6CJI | Candida albicans HSP90 nucleotide binding domain | x-ray diffraction | A | — | — |
| 6CJJ | Candida albicans Hsp90 nucleotide binding domain in complex with ADP | x-ray diffraction | A | MG, ADP | 1 (best 0.60) |
| 6CJJ | Candida albicans HSP90 nucleotide binding domain in complex with ADP | x-ray diffraction | A | MG, ADP | — |
| 6CJL | Candida albicans Hsp90 nucleotide binding domain in complex with radicicol | x-ray diffraction | A, B | RDC, MG | 3 (best 0.73) |
| 6CJL | Candida albicans HSP90 nucleotide binding domain in complex with radicicol | x-ray diffraction | A, B | RDC, MG | — |
| 6CJP | Candida albicans Hsp90 nucleotide binding domain in complex with radicicol | x-ray diffraction | A, B | F5S | 5 (best 0.67) |
| 6CJP | Candida albicans HSP90 nucleotide binding domain in complex with radicicol | x-ray diffraction | A, B | F5S | — |
| 6CJR | Candida albicans Hsp90 nucleotide binding domain in complex with SNX-2112 | x-ray diffraction | A, B | E0G | — |
| 6CJR | Candida albicans HSP90 nucleotide binding domain in complex with snx- 2112 | x-ray diffraction | A, B | E0G | — |
| 6CJS | Candida albicans Hsp90 nucleotide binding domain in complex with AUY922 | x-ray diffraction | A | 2GJ | 1 (best 0.67) |
| 6CJS | Candida albicans HSP90 nucleotide binding domain in complex with AUY922 | x-ray diffraction | A | 2GJ | — |
| P46598 | AlphaFold monomer V2.0 prediction for heat shock protein 90 homolog (P46598) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 4 records
- 2GJ · 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide · in 2 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- E0G · 4-[6,6-dimethyl-4-oxidanylidene-3-(trifluoromethyl)-5, 7-dihydroindazol-1-yl]-2-[(4-oxidanylcyclohexyl) amino]benzamide · in 2 records
- F5S · (1ar,2z,4e,6e,14r,15ar)-9,11-dihydroxy-6-{[(4-methoxyphenyl)methoxy]imino}-14-methyl-1A,6,7,14,15, 15A-hexahydro-12H-oxireno[e][2]benzoxacyclotetradecin-12-one · in 2 records
- RDC · Radicicol · in 2 records
Experiment against prediction
- 6CJP chain B against the predicted model P46598: TM-score 0.88, RMSD 2.47 Å
- 6CJP chain B against the predicted model P46598: TM-score 0.88, RMSD 2.47 Å
- 6CJR chain B against the predicted model P46598: TM-score 0.82, RMSD 2.27 Å
- 6CJR chain B against the predicted model P46598: TM-score 0.82, RMSD 2.27 Å
- 6CJL chain A against the predicted model P46598: TM-score 0.82, RMSD 2.17 Å
- 6CJL chain A against the predicted model P46598: TM-score 0.82, RMSD 2.17 Å
- 6CJJ chain A against the predicted model P46598: TM-score 0.82, RMSD 2.13 Å
- 6CJJ chain A against the predicted model P46598: TM-score 0.82, RMSD 2.13 Å
- 6CJI chain A against the predicted model P46598: TM-score 0.82, RMSD 2.16 Å
- 6CJL chain B against the predicted model P46598: TM-score 0.81, RMSD 2.08 Å
Elsewhere
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