UniProt P46527
Cyclin-dependent kinase inhibitor 1B (P46527)
Cyclin-dependent kinase inhibitor 1B (UniProt P46527): 23 experimental structures and 1 predicted model on GenesisL1, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P46527
- Protein
- Cyclin-dependent kinase inhibitor 1B
- Experimental structures
- 23
- Predicted models
- 1
- Pockets
- 1 · 1 record with a druggable one
Structures
24 records of P46527 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1H27 | CDK2/CyclinA in complex with an 11-residue recruitment peptide from p27 | x-ray diffraction | E | — | — |
| 1H27 | CDK2/CYCLIN a in complex with an 11-residue recruitment peptide from P27 | x-ray diffraction | E | — | — |
| 1JSU | P27(KIP1)/CYCLIN A/CDK2 complex | x-ray diffraction | C | — | — |
| 1JSU | P27(KIP1)/CYCLIN A/CDK2 complex | x-ray diffraction | C | — | — |
| 2AST | Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide | x-ray diffraction | D | — | — |
| 2AST | Crystal structure of SKP1-SKP2-CKS1 in complex with a P27 peptide | x-ray diffraction | D | — | — |
| 5UQ3 | Crystal structure of human CDK2-SPY1-P27 ternary complex | x-ray diffraction | C | — | — |
| 6ATH | CDK2/CYCLIN A/P27-kid-deltac | x-ray diffraction | C | — | — |
| 6P8E | Crystal structure of CDK4 in complex with CYCLIND1 and P27 | x-ray diffraction | C | — | — |
| 6P8F | Crystal structure of CDK4 in complex with CYCLIND1 and P27 | x-ray diffraction | C | — | — |
| 6P8G | Crystal structure of CDK4 in complex with CyclinD1 and P27 | x-ray diffraction | C | — | — |
| 6P8G | Crystal structure of CDK4 in complex with CYCLIND1 and P27 | x-ray diffraction | C | — | — |
| 7B5L | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly… | electron microscopy | P | — | — |
| 7B5L | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | P | — | — |
| 7B5M | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | P | — | — |
| 7B5R | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | P | — | — |
| 7OR8 | Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ136 | x-ray diffraction | P | — | 1 (best 0.57) |
| 7OR8 | Ternary complex of 14-3-3 sigma, P27PT198 phosphopeptide, and WQ136 | x-ray diffraction | P | — | — |
| 7ORG | Ternary complex of 14-3-3 sigma, P27PT198 phosphopeptide, and WQ162 | x-ray diffraction | P | — | — |
| 7ORH | Ternary complex of 14-3-3 sigma, P27PT198 phosphopeptide, and WQ178 | x-ray diffraction | P | — | — |
| 7ORS | Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ147 | x-ray diffraction | P | — | — |
| 7ORS | Ternary complex of 14-3-3 sigma, P27PT198 phosphopeptide, and WQ147 | x-ray diffraction | P | — | — |
| 7ORT | Ternary complex of 14-3-3 sigma, P27PT198 phosphopeptide, and WQ176 | x-ray diffraction | P | — | — |
| P46527 | AlphaFold monomer V2.0 prediction for cyclin-dependent kinase inhibitor 1B (P46527) | predicted | A | — | — |
Experiment against prediction
- 6P8F chain C against the predicted model P46527: TM-score 0.87, RMSD 1.11 Å
- 6P8G chain C against the predicted model P46527: TM-score 0.84, RMSD 1.23 Å
- 6P8G chain C against the predicted model P46527: TM-score 0.84, RMSD 1.23 Å
- 6P8E chain C against the predicted model P46527: TM-score 0.84, RMSD 1.35 Å
- 5UQ3 chain C against the predicted model P46527: TM-score 0.83, RMSD 1.22 Å
- 7ORG chain P against the predicted model P46527: TM-score 0.78, RMSD 0.46 Å
- 7OR8 chain P against the predicted model P46527: TM-score 0.77, RMSD 0.47 Å
- 7OR8 chain P against the predicted model P46527: TM-score 0.77, RMSD 0.47 Å
- 7ORH chain P against the predicted model P46527: TM-score 0.77, RMSD 0.47 Å
- 1JSU chain C against the predicted model P46527: TM-score 0.73, RMSD 1.94 Å
Elsewhere
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