UniProt P45985
Dual specificity mitogen-activated protein kinase kinase 4 (P45985)
Dual specificity mitogen-activated protein kinase kinase 4 (UniProt P45985): 6 experimental structures and 1 predicted model on GenesisL1, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P45985
- Protein
- Dual specificity mitogen-activated protein kinase kinase 4
- Experimental structures
- 6
- Predicted models
- 1
- Pockets
- 6 · 1 record with a druggable one
Structures
7 records of P45985 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3ALN | Crystal Structure of human non-phosphorylated MKK4 kinase domain complexed with AMP-PNP | x-ray diffraction | A, B, C | — | — |
| 3ALN | Crystal structure of human non-phosphorylated MKK4 kinase domain complexed with AMP-pnp | x-ray diffraction | A, B, C | — | — |
| 3ALO | Crystal structure of human non-phosphorylated MKK4 kinase domain ternary complex with AMP-PNP and… | x-ray diffraction | A | — | — |
| 3ALO | Crystal structure of human non-phosphorylated MKK4 kinase domain ternary complex with AMP-pnp and… | x-ray diffraction | A | — | — |
| 3VUT | Crystal structures of non-phosphorylated MAP2K4 | x-ray diffraction | A, B | — | — |
| 3VUT | Crystal structures of non-phosphorylated MAP2K4 | x-ray diffraction | A, B | — | — |
| P45985 | AlphaFold monomer V2.0 prediction for dual specificity mitogen- activated protein kinase kinase 4… | predicted | A | — | 6 (best 0.72) |
Experiment against prediction
- 3ALN chain C against the predicted model P45985: TM-score 0.96, RMSD 1.26 Å
- 3ALN chain C against the predicted model P45985: TM-score 0.96, RMSD 1.26 Å
- 3ALN chain B against the predicted model P45985: TM-score 0.95, RMSD 1.07 Å
- 3ALN chain B against the predicted model P45985: TM-score 0.95, RMSD 1.07 Å
- 3VUT chain A against the predicted model P45985: TM-score 0.93, RMSD 1.59 Å
- 3VUT chain A against the predicted model P45985: TM-score 0.93, RMSD 1.59 Å
- 3ALN chain A against the predicted model P45985: TM-score 0.92, RMSD 1.75 Å
- 3ALN chain A against the predicted model P45985: TM-score 0.92, RMSD 1.75 Å
- 3ALO chain A against the predicted model P45985: TM-score 0.90, RMSD 1.86 Å
- 3ALO chain A against the predicted model P45985: TM-score 0.90, RMSD 1.86 Å
Elsewhere
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