UniProt P41597
C-C chemokine receptor type 2,Rubredoxin,C-C chemokine receptor type 2 (P41597)
C-C chemokine receptor type 2,Rubredoxin,C-C chemokine receptor type 2 (UniProt P41597), EC 3.2.1.17: 10 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 19 pockets. Binding sites, druggability and…
- UniProt
- P41597
- Protein
- C-C chemokine receptor type 2,Rubredoxin,C-C chemokine receptor type 2
- EC
- 3.2.1.17
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 19 · 3 records with a druggable one
Structures
11 records of P41597 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5T1A | Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists | x-ray diffraction | A | 73R, VT5, SO4, ZN | 6 (best 0.78) |
| 5T1A | Structure of cc chemokine receptor 2 with orthosteric and allosteric antagonists | x-ray diffraction | A | 73R, VT5, SO4, ZN | — |
| 6GPS | Crystal structure of CCR2A in complex with mk-0812 | x-ray diffraction | A | ZN, F7N | — |
| 6GPS | Crystal structure of CCR2A in complex with mk-0812 | x-ray diffraction | A | ZN, F7N | — |
| 6GPX | Crystal structure of CCR2A in complex with mk-0812 | x-ray diffraction | A, B | ZN, OLA, F7N | 9 (best 0.74) |
| 6GPX | Crystal structure of CCR2A in complex with mk-0812 | x-ray diffraction | A, B | ZN, OLA, F7N | — |
| 7P8X | Crystal Structure of leukotoxin LukE from Staphylococcus aureus in complex with a doubly sulfated… | x-ray diffraction | M | — | — |
| 7P8X | Crystal structure of leukotoxin luke from staphylococcus aureus in complex with a doubly sulfated… | x-ray diffraction | M | ACE | — |
| 7XA3 | Cryo-EM structure of the CCL2 bound CCR2-Gi complex | electron microscopy | R | — | 4 (best 0.80) |
| 7XA3 | Cryo-EM structure of the CCL2 bound CCR2-gi complex | electron microscopy | R | — | — |
| P41597 | AlphaFold monomer V2.0 prediction for C-C chemokine receptor type 2 (P41597) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 6 records
- F7N · [(3~{S},4~{S})-3-methoxyoxan-4-yl]-[(1~{R},3~{S})-3-propan-2-yl-3-[[3-(trifluoromethyl)-7,8-dihydro-5~{H}-1,6-naphthyridin-6-yl]carbonyl]cyclopentyl]azanium · in 4 records
- 73R · (3S)-1-{(1S,2R,4R)-4-[methyl(propan-2-yl)amino]-2-propylcyclohexyl}-3-{[6-(trifluoromethyl)quinazolin-4-yl]amino}pyrrolidin-2-one · in 2 records
- OLA · Oleic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- VT5 · (2~{R})-1-(4-chloranyl-2-fluoranyl-phenyl)-2-cyclohexyl-3-ethanoyl-4-oxidanyl-2~{H}-pyrrol-5-one · in 2 records
- ACE · Acetyl group · in 1 record
Experiment against prediction
- 6GPX chain B against the predicted model P41597: TM-score 0.98, RMSD 1.03 Å
- 6GPX chain B against the predicted model P41597: TM-score 0.98, RMSD 1.03 Å
- 6GPX chain A against the predicted model P00268: TM-score 0.16, RMSD 0.43 Å
- 6GPX chain A against the predicted model P00268: TM-score 0.16, RMSD 0.43 Å
- 6GPS chain A against the predicted model P00268: TM-score 0.16, RMSD 0.65 Å
- 6GPS chain A against the predicted model P00268: TM-score 0.16, RMSD 0.65 Å
- 7XA3 chain R against the predicted model P41597: TM-score 0.92, RMSD 2.14 Å
- 7XA3 chain R against the predicted model P41597: TM-score 0.92, RMSD 2.14 Å
- 6GPX chain A against the predicted model P41597: TM-score 0.83, RMSD 1.21 Å
- 6GPX chain A against the predicted model P41597: TM-score 0.83, RMSD 1.21 Å
Elsewhere
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