UniProt P41159
Leptin (P41159)
Leptin (UniProt P41159): 10 experimental structures and 1 predicted model on GenesisL1, 54 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P41159
- Protein
- Leptin
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 54 · 8 records with a druggable one
Structures
11 records of P41159 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AX8 | Human obesity protein, leptin | x-ray diffraction | A | — | — |
| 1AX8 | Human obesity protein, leptin | x-ray diffraction | A | — | — |
| 7Z3Q | Crystal structure of the human leptin:LepR-CRH2 encounter complex to 3.6 A resolution. | x-ray diffraction | A, C, E | — | 11 (best 0.73) |
| 8AVE | Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine… | electron microscopy | A, C | — | 8 (best 0.57) |
| 8AVF | Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine… | electron microscopy | A, C, E | — | 12 (best 0.63) |
| 8AVO | Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine… | electron microscopy | A, C, E | — | 6 (best 0.52) |
| 8K6Z | NMR structure of human leptin | solution nmr | A | — | 1 (best 0.53) |
| 8X80 | Structure of leptin-LepR trimer with a small gap | electron microscopy | E, D, F | — | 6 (best 0.73) |
| 8X81 | Structure of leptin-LepR trimer with a large gap | electron microscopy | D, F, E | — | 4 (best 0.69) |
| 8X85 | Structure of leptin-LepR dimer | electron microscopy | C, D | — | 6 (best 0.67) |
| P41159 | AlphaFold monomer V2.0 prediction for leptin (P41159) | predicted | A | — | — |
Experiment against prediction
- 7Z3Q chain A against the predicted model P41159: TM-score 0.96, RMSD 0.81 Å
- 7Z3Q chain E against the predicted model P41159: TM-score 0.94, RMSD 1.04 Å
- 7Z3Q chain C against the predicted model P41159: TM-score 0.93, RMSD 1.35 Å
- 8X85 chain D against the predicted model P41159: TM-score 0.92, RMSD 1.11 Å
- 8AVF chain E against the predicted model P41159: TM-score 0.92, RMSD 1.78 Å
- 8AVF chain C against the predicted model P41159: TM-score 0.92, RMSD 1.78 Å
- 8AVF chain A against the predicted model P41159: TM-score 0.92, RMSD 1.78 Å
- 8AVO chain C against the predicted model P41159: TM-score 0.92, RMSD 1.75 Å
- 8AVO chain A against the predicted model P41159: TM-score 0.92, RMSD 1.75 Å
- 8AVO chain E against the predicted model P41159: TM-score 0.92, RMSD 1.75 Å
Elsewhere
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