UniProt P40879

Chloride anion exchanger (P40879)

Chloride anion exchanger (UniProt P40879): 2 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 49 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P40879
Protein: Chloride anion exchanger
Experimental structures: 2
Predicted models: 1
Ligands: 3
Pockets: 49 · 3 records with a druggable one

Structures

3 records of P40879 in the MolNFT archive: 2 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
7XUH	Down-regulated in adenoma in complex with TQR1122	electron microscopy	A, B	I2L, Y01	20 (best 0.85)
7XUL	Human SLC26A3 in complex with Tenidap	electron microscopy	A, B	I2U, Y01	20 (best 0.86)
P40879	AlphaFold monomer V2.0 prediction for chloride anion exchanger (P40879)	predicted	A	—	9 (best 0.73)

Ligands

Y01 · Cholesterol hemisuccinate · in 2 records
I2L · 2-[4,8-dimethyl-2-oxidanylidene-7-[[3-(trifluoromethyl)phenyl]methoxy]chromen-3-yl]ethanoic acid · in 1 record
I2U · 5-chloranyl-2-oxidanyl-3-thiophen-2-ylcarbonyl-indole-1-carboxamide · in 1 record

Experiment against prediction

7XUL chain A against the predicted model P40879: TM-score 0.94, RMSD 2.34 Å
7XUL chain B against the predicted model P40879: TM-score 0.94, RMSD 2.34 Å
7XUH chain B against the predicted model P40879: TM-score 0.93, RMSD 2.64 Å
7XUH chain A against the predicted model P40879: TM-score 0.93, RMSD 2.64 Å

Elsewhere

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