UniProt P40327
26S proteasome regulatory subunit 4 homolog (P40327)
26S proteasome regulatory subunit 4 homolog (UniProt P40327): 37 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 78 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P40327
- Protein
- 26S proteasome regulatory subunit 4 homolog
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 78 · 17 records with a druggable one
Structures
38 records of P40327 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JCO | Structure of yeast 26S proteasome in M1 state derived from Titan dataset | electron microscopy | I | — | — |
| 3JCP | Structure of yeast 26S proteasome in M2 state derived from Titan dataset | electron microscopy | I | — | — |
| 4CR2 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | I | — | — |
| 4CR2 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | I | — | — |
| 4CR3 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | I | — | — |
| 4CR3 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | I | — | — |
| 4CR4 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | I | — | — |
| 4CR4 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | I | — | — |
| 5A5B | Structure of the 26S proteasome-Ubp6 complex | electron microscopy | I | — | — |
| 5A5B | Structure of the 26S proteasome-UBP6 complex | electron microscopy | I | — | — |
| 5MP9 | 26S proteasome in presence of ATP (s1) | electron microscopy | I | ATP, MG | — |
| 5MP9 | 26S proteasome in presence of ATP (S1) | electron microscopy | I | ATP, MG | — |
| 5MPA | 26S proteasome in presence of ATP (s2) | electron microscopy | I | ATP, MG | 4 (best 0.80) |
| 5MPA | 26S proteasome in presence of ATP (S2) | electron microscopy | I | ATP, MG | — |
| 5MPB | 26S proteasome in presence of AMP-PNP (s3) | electron microscopy | I | ANP, MG | 3 (best 0.82) |
| 5MPC | 26S proteasome in presence of BeFx (s4) | electron microscopy | I | ATP, MG | — |
| 5WVI | The resting state of yeast proteasome | electron microscopy | I | — | — |
| 5WVK | Yeast proteasome-ADP-AlFx | electron microscopy | I | — | 1 (best 0.84) |
| 6EF0 | Yeast 26S proteasome bound to ubiquitinated substrate (1D* motor state) | electron microscopy | I | ADP, ATP | 6 (best 0.84) |
| 6EF0 | Yeast 26S proteasome bound to ubiquitinated substrate (1D* motor state) | electron microscopy | I | ADP, ATP | — |
| 6EF1 | Yeast 26S proteasome bound to ubiquitinated substrate (5D motor state) | electron microscopy | I | ATP | 6 (best 0.90) |
| 6EF1 | Yeast 26S proteasome bound to ubiquitinated substrate (5D motor state) | electron microscopy | I | ATP | — |
| 6EF2 | Yeast 26S proteasome bound to ubiquitinated substrate (5T motor state) | electron microscopy | I | ATP | 7 (best 0.81) |
| 6EF2 | Yeast 26S proteasome bound to ubiquitinated substrate (5T motor state) | electron microscopy | I | ATP | — |
| 6EF3 | Yeast 26S proteasome bound to ubiquitinated substrate (4D motor state) | electron microscopy | I | ATP | 7 (best 0.82) |
| 6EF3 | Yeast 26S proteasome bound to ubiquitinated substrate (4D motor state) | electron microscopy | I | ATP | — |
| 6FVT | 26S proteasome, s1 state | electron microscopy | I | ATP, MG | — |
| 6FVU | 26S proteasome, s2 state | electron microscopy | I | ATP, MG | 5 (best 0.80) |
| 6FVV | 26S proteasome, s3 state | electron microscopy | I | ADP, ATP, MG | 6 (best 0.84) |
| 6FVW | 26S proteasome, s4 state | electron microscopy | I | ATP, MG | 5 (best 0.83) |
| 6FVX | 26S proteasome, s5 state | electron microscopy | I | ATP, MG | 4 (best 0.83) |
| 6FVY | 26S proteasome, s6 state | electron microscopy | I | ATP, MG | 3 (best 0.80) |
| 6J2C | Yeast proteasome in translocation competent state (C3-a) | electron microscopy | I | — | 3 (best 0.81) |
| 6J2N | yeast proteasome in substrate-processing state (C3-b) | electron microscopy | I | — | 2 (best 0.84) |
| 6J2X | Yeast proteasome in resting state (C1-a) | electron microscopy | I | — | — |
| 6J30 | yeast proteasome in Ub-engaged state (C2) | electron microscopy | I | — | 6 (best 0.84) |
| 7QO5 | 26S proteasome Rpt1-RK -Ubp6-UbVS complex in the si state | electron microscopy | I | ATP, MG | 5 (best 0.83) |
| P40327 | AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit 4 homolog (P40327) | predicted | A | — | 5 (best 0.56) |
Ligands
Experiment against prediction
- 6J2X chain I against the predicted model P40327: TM-score 0.91, RMSD 2.34 Å
- 6EF2 chain I against the predicted model P40327: TM-score 0.90, RMSD 2.25 Å
- 6EF2 chain I against the predicted model P40327: TM-score 0.90, RMSD 2.25 Å
- 6FVT chain I against the predicted model P40327: TM-score 0.88, RMSD 2.62 Å
- 5WVI chain I against the predicted model P40327: TM-score 0.88, RMSD 2.74 Å
- 5MP9 chain I against the predicted model P40327: TM-score 0.87, RMSD 2.50 Å
- 5MP9 chain I against the predicted model P40327: TM-score 0.87, RMSD 2.50 Å
- 6J30 chain I against the predicted model P40327: TM-score 0.87, RMSD 2.81 Å
- 6EF0 chain I against the predicted model P40327: TM-score 0.87, RMSD 2.53 Å
- 6EF0 chain I against the predicted model P40327: TM-score 0.87, RMSD 2.53 Å
Elsewhere
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