UniProt P39905
Glial cell line-derived neurotrophic factor (P39905)
Glial cell line-derived neurotrophic factor (UniProt P39905): 8 experimental structures and 1 predicted model on GenesisL1, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P39905
- Protein
- Glial cell line-derived neurotrophic factor
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 6 · 1 record with a druggable one
Structures
9 records of P39905 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2V5E | The structure of the GDNF:Coreceptor complex: Insights into RET signalling and heparin binding. | x-ray diffraction | B | — | — |
| 2V5E | The structure of the GDNF:CORECEPTOR complex: insights into ret signalling and heparin binding. | x-ray diffraction | B | — | — |
| 3FUB | Crystal structure of GDNF-GFRalpha1 complex | x-ray diffraction | B, D | — | — |
| 3FUB | Crystal structure of gdnf-GFRALPHA1 complex | x-ray diffraction | B, D | — | — |
| 4UX8 | RET recognition of GDNF-GFRalpha1 ligand by a composite binding site promotes membrane-proximal… | electron microscopy | D, F | — | — |
| 4UX8 | Ret recognition of gdnf-GFRALPHA1 ligand by a composite binding site promotes membrane-proximal… | electron microscopy | D, F | — | — |
| 6Q2N | Cryo-EM structure of RET/GFRa1/GDNF extracellular complex | electron microscopy | A, B | — | 6 (best 0.73) |
| 6Q2N | Cryo-EM structure of RET/GFRA1/GDNF extracellular complex | electron microscopy | A, B | — | — |
| P39905 | AlphaFold monomer V2.0 prediction for glial cell line-derived neurotrophic factor (P39905) | predicted | A | — | — |
Experiment against prediction
- 3FUB chain B against the predicted model P39905: TM-score 0.95, RMSD 1.05 Å
- 3FUB chain B against the predicted model P39905: TM-score 0.95, RMSD 1.05 Å
- 4UX8 chain D against the predicted model P39905: TM-score 0.94, RMSD 1.14 Å
- 4UX8 chain D against the predicted model P39905: TM-score 0.94, RMSD 1.14 Å
- 4UX8 chain F against the predicted model P39905: TM-score 0.94, RMSD 1.14 Å
- 4UX8 chain F against the predicted model P39905: TM-score 0.94, RMSD 1.14 Å
- 3FUB chain D against the predicted model P39905: TM-score 0.88, RMSD 1.73 Å
- 3FUB chain D against the predicted model P39905: TM-score 0.88, RMSD 1.73 Å
- 2V5E chain B against the predicted model P39905: TM-score 0.87, RMSD 1.85 Å
- 2V5E chain B against the predicted model P39905: TM-score 0.87, RMSD 1.85 Å
Elsewhere
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