UniProt P38489
Oxygen-insensitive NAD(P)H nitroreductase (P38489)
Oxygen-insensitive NAD(P)H nitroreductase (UniProt P38489), EC 1.-.-.-, 1.5.1.34: 31 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 10 pockets. Binding sites, druggability and experiment against…
- UniProt
- P38489
- Protein
- Oxygen-insensitive NAD(P)H nitroreductase
- EC
- 1.-.-.-, 1.5.1.34
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 10 · 2 records with a druggable one
Structures
32 records of P38489 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DS7 | A minor FMN-dependent nitroreductase from escherichia COLI B | x-ray diffraction | A, B | — | — |
| 1DS7 | A minor FMN-dependent nitroreductase from escherichia COLI B | x-ray diffraction | A, B | — | — |
| 1ICR | The structure of escherichia COLI nitroreductase complexed with nicotinic acid | x-ray diffraction | A, B | — | — |
| 1ICR | The structure of escherichia COLI nitroreductase complexed with nicotinic acid | x-ray diffraction | A, B | — | — |
| 1ICU | The structure of escherichia COLI nitroreductase complexed with nicotinic acid | x-ray diffraction | A, B, C, D | — | — |
| 1ICU | The structure of escherichia COLI nitroreductase complexed with nicotinic acid | x-ray diffraction | A, B, C, D | — | — |
| 1ICV | The structure of escherichia COLI nitroreductase complexed with nicotinic acid | x-ray diffraction | A, B, C, D | — | — |
| 1ICV | The structure of escherichia COLI nitroreductase complexed with nicotinic acid | x-ray diffraction | A, B, C, D | — | — |
| 1IDT | Structural studies on a prodrug-activating system-CB1954 and FMN-dependent nitroreductase | x-ray diffraction | A, B | — | — |
| 1IDT | Structural studies on a prodrug-activating system-CB1954 and FMN- dependent nitroreductase | x-ray diffraction | A, B | — | — |
| 1OO5 | Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of the Enzyme Active… | x-ray diffraction | A, B | — | — |
| 1OO5 | Studies on the nitroreductase prodrug-activating system. crystal structures of the enzyme active… | x-ray diffraction | A, B | — | — |
| 1OO6 | Nitroreductase from e-coli in complex with the dinitrobenzamide prodrug SN23862 | x-ray diffraction | A, B | — | — |
| 1OO6 | Nitroreductase from E-COLI in complex with the dinitrobenzamide prodrug SN23862 | x-ray diffraction | A, B | — | — |
| 1OON | Nitroreductase from e-coli in complex with the dinitrobenzamide prodrug SN27217 | x-ray diffraction | A, B | — | — |
| 1OON | Nitroreductase from E-COLI in complex with the dinitrobenzamide prodrug SN27217 | x-ray diffraction | A, B | — | — |
| 1OOQ | Nitroreductase from e-coli in complex with the inhibitor dicoumarol | x-ray diffraction | A, B | — | — |
| 1OOQ | Nitroreductase from E-COLI in complex with the inhibitor dicoumarol | x-ray diffraction | A, B | — | — |
| 1YKI | The structure of E. coli nitroreductase bound with the antibiotic nitrofurazone | x-ray diffraction | A, B, C, D | — | — |
| 1YKI | The structure of E. COLI nitroreductase bound with the antibiotic nitrofurazone | x-ray diffraction | A, B, C, D | — | — |
| 1YLR | The structure of E.coli nitroreductase with bound acetate, crystal form 1 | x-ray diffraction | A, B | — | — |
| 1YLR | The structure of E.COLI nitroreductase with bound acetate, crystal form 1 | x-ray diffraction | A, B | — | — |
| 1YLU | The structure of E. coli nitroreductase with bound acetate, crystal form 2 | x-ray diffraction | A, B | — | — |
| 1YLU | The structure of E. COLI nitroreductase with bound acetate, crystal form 2 | x-ray diffraction | A, B | — | — |
| 3X21 | Crystal structure of Escherichia coli nitroreductase NfsB mutant T41L/N71S/F124W | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 3X21 | Crystal structure of escherichia COLI nitroreductase nfsb mutant T41L/N71S/F124W | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 3X22 | Crystal structure of Escherichia coli nitroreductase NfsB mutant N71S/F123A/F124W | x-ray diffraction | A, B | — | — |
| 3X22 | Crystal structure of escherichia COLI nitroreductase nfsb mutant N71S/F123A/F124W | x-ray diffraction | A, B | — | — |
| 8C5F | E. coli NfsB-T41Q/N71S/F124T mutant bound to acetate | x-ray diffraction | A, B | FMN | — |
| 8OG3 | E. coli NfsB triple mutant T41L/N71S/F124T bound to citrate | x-ray diffraction | A, B | FMN | 2 (best 0.73) |
| 8QES | E coli NfsB with the unnatural amino acid, p-aminoPhe at position 124 | x-ray diffraction | A, B, C, D | FMN, NIO | 7 (best 0.75) |
| P38489 | AlphaFold monomer V2.0 prediction for oxygen-insensitive NAD(P)H nitroreductase (P38489) | predicted | A | — | 1 (best 0.39) |
Ligands
Experiment against prediction
- 1ICV chain A against the predicted model P38489: TM-score 1.00, RMSD 0.36 Å
- 1ICV chain A against the predicted model P38489: TM-score 1.00, RMSD 0.36 Å
- 8OG3 chain B against the predicted model P38489: TM-score 1.00, RMSD 0.38 Å
- 3X22 chain A against the predicted model P38489: TM-score 1.00, RMSD 0.38 Å
- 3X22 chain A against the predicted model P38489: TM-score 1.00, RMSD 0.38 Å
- 1IDT chain B against the predicted model P38489: TM-score 1.00, RMSD 0.39 Å
- 1IDT chain B against the predicted model P38489: TM-score 1.00, RMSD 0.39 Å
- 8OG3 chain A against the predicted model P38489: TM-score 1.00, RMSD 0.39 Å
- 1ICR chain A against the predicted model P38489: TM-score 0.99, RMSD 0.40 Å
- 1ICR chain A against the predicted model P38489: TM-score 0.99, RMSD 0.40 Å
Elsewhere
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