UniProt P38377
Protein transport protein Sec61 subunit alpha isoform 1 (P38377)
Protein transport protein Sec61 subunit alpha isoform 1 (UniProt P38377): 19 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 10 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P38377
- Protein
- Protein transport protein Sec61 subunit alpha isoform 1
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 10 · 4 records with a druggable one
Structures
20 records of P38377 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2WWB | Cryo-EM structure of the mammalian SEC61 complex bound to the actively translating wheat germ 80S… | electron microscopy | A | — | — |
| 2WWB | Cryo-EM structure of the mammalian SEC61 complex bound to the actively translating wheat germ 80S… | electron microscopy | A | — | — |
| 3JC2 | The structure of the mammalian Sec61 channel opened by a signal sequence | electron microscopy | 1 | — | — |
| 3JC2 | The structure of the mammalian SEC61 channel opened by a signal sequence | electron microscopy | 1 | — | — |
| 4CG5 | Cryo-EM of the Sec61-complex bound to the 80S ribosome translating a secretory substrate | electron microscopy | A | — | — |
| 4CG5 | Cryo-EM of the SEC61-complex bound to the 80S ribosome translating a secretory substrate | electron microscopy | A | — | — |
| 4CG6 | Cryo-em of the Sec61-complex bound to the 80s ribosome translating a membrane-inserting substrate | electron microscopy | A | — | — |
| 4CG6 | Cryo-EM of the SEC61-complex bound to the 80S ribosome translating a membrane-inserting substrate | electron microscopy | A | — | — |
| 4CG7 | Cryo-EM of the Sec61-complex bound to the idle 80S ribosome | electron microscopy | A | — | — |
| 4CG7 | Cryo-EM of the SEC61-complex bound to the idle 80S ribosome | electron microscopy | A | — | — |
| 5A6U | Native mammalian ribosome-bound Sec61 protein-conducting channel in the 'non-inserting' state | electron microscopy | A | — | — |
| 5A6U | Native mammalian ribosome-bound SEC61 protein-conducting channel in the 'non-inserting' state | electron microscopy | A | — | — |
| 6FTG | Subtomogram average of OST-containing ribosome-translocon complexes from canine rough microsomal… | electron microscopy | x | — | — |
| 6FTJ | Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Non-programmed… | electron microscopy | x | — | — |
| 6Z3T | Structure of canine SEC61 inhibited by mycolactone | electron microscopy | A | Q6B | — |
| 8BTK | Structure of the TRAP complex with the Sec translocon and a translating ribosome | electron microscopy | SX | — | 1 (best 0.88) |
| 8OJ8 | 60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native) | electron microscopy | 1 | — | 1 (best 0.87) |
| 8RJB | Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in complex with… | electron microscopy | 1 | — | — |
| 8RJD | Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in complex with… | electron microscopy | 1 | — | 1 (best 0.85) |
| P38377 | AlphaFold monomer V2.0 prediction for protein transport protein SEC61 subunit alpha isoform 1… | predicted | A | — | 7 (best 0.75) |
Ligands
- Q6B · [(6~{S},7~{S},9~{Z},12~{R})-12-[(~{Z},2~{S},6~{R}, 7~{R},9~{R})-4,6-dimethyl-7,9-bis(oxidanyl)dec-4-en-2-yl]-7,9-dimethyl-2-oxidanylidene-1-oxacyclododec-9-en-6-yl] (2~{E},4~{E},6~{E},8~{E},10~{E},12~{S},13~{S}, 15~{S})-4,6,10-trimethyl-12,13,15-tris(oxidanyl) hexadeca-2,4,6,8,10-pentaenoate · in 1 record
Experiment against prediction
- 8RJB chain 1 against the predicted model P38377: TM-score 0.96, RMSD 1.72 Å
- 6Z3T chain A against the predicted model P38377: TM-score 0.93, RMSD 2.13 Å
- 6FTJ chain x against the predicted model P38377: TM-score 0.91, RMSD 2.40 Å
- 6FTG chain x against the predicted model P38377: TM-score 0.90, RMSD 2.48 Å
- 8OJ8 chain 1 against the predicted model P38377: TM-score 0.90, RMSD 2.57 Å
- 8BTK chain SX against the predicted model P38377: TM-score 0.89, RMSD 2.67 Å
- 8RJD chain 1 against the predicted model P38377: TM-score 0.86, RMSD 3.14 Å
- 3JC2 chain 1 against the predicted model P38377: TM-score 0.85, RMSD 3.13 Å
- 3JC2 chain 1 against the predicted model P38377: TM-score 0.85, RMSD 3.13 Å
- 5A6U chain A against the predicted model P38377: TM-score 0.84, RMSD 3.29 Å
Elsewhere
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