UniProt P35226
Polycomb complex protein BMI-1 (P35226)
Polycomb complex protein BMI-1 (UniProt P35226), EC 5.-.-.-: 14 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P35226
- Protein
- Polycomb complex protein BMI-1
- EC
- 5.-.-.-
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 7 · 3 records with a druggable one
Structures
15 records of P35226 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2NA1 | ULD complex | solution nmr | A | — | — |
| 2NA1 | ULD COMPLEX | solution nmr | A | — | — |
| 3RPG | Bmi1/Ring1b-UbcH5c complex structure | x-ray diffraction | B | — | — |
| 3RPG | BMI1/RING1B-UBCH5C complex structure | x-ray diffraction | B | — | — |
| 4R8P | Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core… | x-ray diffraction | K, M | — | — |
| 4R8P | Crystal structure of the RING1B/BMI1/UBCH5C PRC1 ubiquitylation module bound to the nucleosome core… | x-ray diffraction | K, M | — | — |
| 5FR6 | The structure of polycomb ULD complex | x-ray diffraction | A | — | — |
| 5FR6 | The structure of polycomb uld complex | x-ray diffraction | A | — | — |
| 6WI7 | RING1B-BMI1 fusion in closed conformation | x-ray diffraction | A | ZN | — |
| 6WI8 | Inhibitor compound-induced confrontational change in Ring1b-Bmi1 domain structure | x-ray diffraction | A, B | ZN | 4 (best 0.73) |
| 6WI8 | Inhibitor compound-induced confrontational change in RING1B-BMI1 domain structure | x-ray diffraction | A, B | ZN | — |
| 7ND1 | First-in-class small molecule inhibitors of polycomb repressive complex 1 (PRC1) ring domain | solution nmr | H | ZN | — |
| 9DBY | ncPRC1RYBP bound to singly modified H2AK119Ub nucleosome | electron microscopy | K | ZN | 1 (best 0.57) |
| 9DDE | ncPRC1RYBP bound to H2AK119Ub/H1.4 chromatosome | electron microscopy | K | ZN | 2 (best 0.63) |
| P35226 | AlphaFold monomer V2.0 prediction for polycomb complex protein bmi-1 (P35226) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 6 records
Experiment against prediction
- 5FR6 chain A against the predicted model P35226: TM-score 0.99, RMSD 0.36 Å
- 5FR6 chain A against the predicted model P35226: TM-score 0.99, RMSD 0.36 Å
- 3RPG chain B against the predicted model P35226: TM-score 0.99, RMSD 0.44 Å
- 3RPG chain B against the predicted model P35226: TM-score 0.99, RMSD 0.44 Å
- 7ND1 chain H against the predicted model P35226: TM-score 0.99, RMSD 0.47 Å
- 4R8P chain M against the predicted model P35226: TM-score 0.98, RMSD 0.50 Å
- 4R8P chain M against the predicted model P35226: TM-score 0.98, RMSD 0.50 Å
- 4R8P chain K against the predicted model P35226: TM-score 0.97, RMSD 0.71 Å
- 4R8P chain K against the predicted model P35226: TM-score 0.97, RMSD 0.71 Å
- 9DDE chain K against the predicted model P35226: TM-score 0.96, RMSD 0.86 Å
Elsewhere
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