UniProt P34947
G protein-coupled receptor kinase 5 (P34947)
G protein-coupled receptor kinase 5 (UniProt P34947), EC 2.7.11.16: 7 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P34947
- Protein
- G protein-coupled receptor kinase 5
- EC
- 2.7.11.16
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 15 · 2 records with a druggable one
Structures
8 records of P34947 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4TNB | Crystal Structure of G Protein-Coupled Receptor Kinase 5 in Complex with Sangivamycin | x-ray diffraction | A | — | — |
| 4TNB | Crystal structure of G protein-coupled receptor kinase 5 in complex with sangivamycin | x-ray diffraction | A | — | — |
| 4TND | Crystal Structure of G Protein-Coupled Receptor Kinase 5 in Complex with AMP-PNP | x-ray diffraction | A | — | — |
| 4TND | Crystal structure of G protein-coupled receptor kinase 5 in complex with AMP-pnp | x-ray diffraction | A | — | — |
| 6PJX | Crystal Structure of G Protein-Coupled Receptor Kinase 5 (GRK5) in Complex with Calmodulin (CaM) | x-ray diffraction | A | SGV | 8 (best 0.77) |
| 6PJX | Crystal structure of G protein-coupled receptor kinase 5 (GRK5) in complex with calmodulin (cam) | x-ray diffraction | A | ACE, SGV | — |
| 8UAP | Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 D311N in Complex with CCG273441 | x-ray diffraction | A | W2T | 7 (best 0.68) |
| P34947 | AlphaFold monomer V2.0 prediction for G protein-coupled receptor kinase 5 (P34947) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8UAP chain A against the predicted model P34947: TM-score 0.96, RMSD 1.60 Å
- 4TNB chain A against the predicted model P34947: TM-score 0.95, RMSD 1.65 Å
- 4TNB chain A against the predicted model P34947: TM-score 0.95, RMSD 1.65 Å
- 4TND chain A against the predicted model P34947: TM-score 0.94, RMSD 1.66 Å
- 4TND chain A against the predicted model P34947: TM-score 0.94, RMSD 1.66 Å
- 6PJX chain A against the predicted model P34947: TM-score 0.89, RMSD 3.03 Å
- 6PJX chain A against the predicted model P34947: TM-score 0.89, RMSD 3.03 Å
Elsewhere
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