UniProt P33992
DNA replication licensing factor MCM5 (P33992)
DNA replication licensing factor MCM5 (UniProt P33992), EC 3.6.4.12: 19 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 114 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P33992
- Protein
- DNA replication licensing factor MCM5
- EC
- 3.6.4.12
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 114 · 17 records with a druggable one
Structures
20 records of P33992 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6XTX | CryoEM structure of human CMG bound to ATPgammaS and DNA | electron microscopy | 5 | ADP, ZN | 6 (best 0.87) |
| 6XTX | Cryoem structure of human cmg bound to atpgammas and DNA | electron microscopy | 5 | ADP, ZN | — |
| 6XTY | Cryoem structure of human cmg bound to and-1 (cmga) | electron microscopy | 5 | ZN | — |
| 7PFO | Core human replisome | electron microscopy | 5 | ANP, MG, ZN | 9 (best 0.89) |
| 7PLO | H. sapiens replisome-CUL2/LRR1 complex | electron microscopy | 5 | ANP, MG, ZN | 9 (best 0.90) |
| 7W1Y | Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA) | electron microscopy | 5, D | MG, ATP, ZN, ADP | 10 (best 0.89) |
| 7W68 | human single hexameric Mcm2-7 complex | electron microscopy | D | — | 4 (best 0.87) |
| 8B9D | Human replisome bound by Pol Alpha | electron microscopy | 5 | ANP, MG, ZN | 7 (best 0.86) |
| 8S09 | H. sapiens MCM2-7 double hexamer bound to double stranded DNA | electron microscopy | 5, D | ADP, MG, ZN | 8 (best 0.89) |
| 8S0A | H. sapiens MCM2-7 hexamer bound to double stranded DNA | electron microscopy | 5 | ADP, MG, ZN | 6 (best 0.86) |
| 8S0B | H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex | electron microscopy | 5 | ADP, MG, ZN | 8 (best 0.84) |
| 8S0D | H. sapiens MCM bound to double stranded DNA and ORC1-6 | electron microscopy | 5 | ADP, MG, ZN | 6 (best 0.85) |
| 8S0E | H. sapiens OCCM bound to double stranded DNA | electron microscopy | 5 | — | 1 (best 0.80) |
| 8S0F | H. sapiens OC1M bound to double stranded DNA | electron microscopy | 5 | — | 2 (best 0.83) |
| 8W0E | Cryo-EM structure of a human MCM2-7 single hexamer on dsDNA | electron microscopy | 5 | MG, ADP, ZN | 7 (best 0.80) |
| 8W0F | Cryo-EM structure of a human MCM2-7 double hexamer on dsDNA | electron microscopy | 5, D | MG, ADP, ZN | 11 (best 0.88) |
| 8W0G | Cryo-EM structure of a human MCM2-7 dimer | electron microscopy | 5, D | MG, ADP, ZN | 6 (best 0.87) |
| 8W0I | Cryo-EM structure of the human MCM2-7 heterohexamer | electron microscopy | 5 | ADP, ZN | 5 (best 0.87) |
| 9CAQ | Cryo-EM structure of a human MCM2-7 double hexamer formed from independently loaded MCM2-7 single… | electron microscopy | 5, D | ADP, ZN, MG | 9 (best 0.88) |
| P33992 | AlphaFold monomer V2.0 prediction for DNA replication licensing factor MCM5 (P33992) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8S0F chain 5 against the predicted model P33992: TM-score 0.96, RMSD 1.26 Å
- 8S0E chain 5 against the predicted model P33992: TM-score 0.96, RMSD 1.27 Å
- 8W0I chain 5 against the predicted model P33992: TM-score 0.77, RMSD 3.87 Å
- 8W0G chain 5 against the predicted model P33992: TM-score 0.76, RMSD 3.88 Å
- 8W0G chain D against the predicted model P33992: TM-score 0.76, RMSD 3.91 Å
- 7PLO chain 5 against the predicted model P33992: TM-score 0.73, RMSD 5.39 Å
- 7PFO chain 5 against the predicted model P33992: TM-score 0.73, RMSD 5.34 Å
- 8B9D chain 5 against the predicted model P33992: TM-score 0.72, RMSD 5.53 Å
- 7W68 chain D against the predicted model P33992: TM-score 0.71, RMSD 3.76 Å
- 8W0E chain 5 against the predicted model P33992: TM-score 0.69, RMSD 5.88 Å
Elsewhere
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