UniProt P33991
DNA replication licensing factor MCM4 (P33991)
DNA replication licensing factor MCM4 (UniProt P33991), EC 3.6.4.12: 10 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 59 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P33991
- Protein
- DNA replication licensing factor MCM4
- EC
- 3.6.4.12
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 59 · 8 records with a druggable one
Structures
11 records of P33991 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6XTX | Cryoem structure of human cmg bound to atpgammas and DNA | electron microscopy | 4 | ZN, AGS, MG | — |
| 6XTY | Cryoem structure of human cmg bound to and-1 (cmga) | electron microscopy | 4 | ZN | — |
| 7PLO | H. sapiens replisome-CUL2/LRR1 complex | electron microscopy | 4 | ZN | 7 (best 0.86) |
| 8S09 | H. sapiens MCM2-7 double hexamer bound to double stranded DNA | electron microscopy | 4, C | ZN, ADP, MG | 11 (best 0.88) |
| 8S0B | H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex | electron microscopy | 4 | ZN, ADP, AGS, MG | 10 (best 0.86) |
| 8S0D | H. sapiens MCM bound to double stranded DNA and ORC1-6 | electron microscopy | 4 | ZN, ADP, AGS, MG | 7 (best 0.87) |
| 8S0E | H. sapiens OCCM bound to double stranded DNA | electron microscopy | 4 | ZN, AGS, MG | 4 (best 0.85) |
| 8S0F | H. sapiens OC1M bound to double stranded DNA | electron microscopy | 4 | ZN, AGS, MG | 2 (best 0.85) |
| 8W0F | Cryo-EM structure of a human MCM2-7 double hexamer on dsDNA | electron microscopy | 4, C | ZN, MG, ADP | 11 (best 0.88) |
| 8W0I | Cryo-EM structure of the human MCM2-7 heterohexamer | electron microscopy | 4 | ZN, MG, ATP | 7 (best 0.88) |
| P33991 | AlphaFold monomer V2.0 prediction for DNA replication licensing factor MCM4 (P33991) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6XTY chain 4 against the predicted model P33991: TM-score 0.94, RMSD 2.39 Å
- 7PLO chain 4 against the predicted model P33991: TM-score 0.93, RMSD 2.58 Å
- 8S0D chain 4 against the predicted model P33991: TM-score 0.91, RMSD 2.86 Å
- 8S0B chain 4 against the predicted model P33991: TM-score 0.91, RMSD 2.86 Å
- 6XTX chain 4 against the predicted model P33991: TM-score 0.91, RMSD 2.86 Å
- 8S09 chain 4 against the predicted model P33991: TM-score 0.90, RMSD 3.13 Å
- 8S09 chain C against the predicted model P33991: TM-score 0.90, RMSD 3.13 Å
- 8W0F chain C against the predicted model P33991: TM-score 0.87, RMSD 3.61 Å
- 8W0F chain 4 against the predicted model P33991: TM-score 0.87, RMSD 3.63 Å
- 8S0F chain 4 against the predicted model P33991: TM-score 0.77, RMSD 4.54 Å
Elsewhere
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