UniProt P33298

26S proteasome regulatory subunit 6B homolog (P33298)

26S proteasome regulatory subunit 6B homolog (UniProt P33298): 40 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 84 pockets. Binding sites, druggability and experiment against prediction (TM-score)…

UniProt: P33298
Protein: 26S proteasome regulatory subunit 6B homolog
Experimental structures: 40
Predicted models: 1
Ligands: 4
Pockets: 84 · 15 records with a druggable one

Structures

41 records of P33298 in the MolNFT archive: 40 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
2DZN	Crystal structure analysis of yeast Nas6p complexed with the proteasome subunit, rpt3	x-ray diffraction	B, D, F	—	—
2DZN	Crystal structure analysis of yeast NAS6P complexed with the proteasome subunit, RPT3	x-ray diffraction	B, D, F	—	—
2DZO	Crystal structure analysis of yeast Nas6p complexed with the proteasome subunit, rpt3	x-ray diffraction	B, D	—	—
2DZO	Crystal structure analysis of yeast NAS6P complexed with the proteasome subunit, RPT3	x-ray diffraction	B, D	—	—
3JCO	Structure of yeast 26S proteasome in M1 state derived from Titan dataset	electron microscopy	K	—	—
3JCP	Structure of yeast 26S proteasome in M2 state derived from Titan dataset	electron microscopy	K	—	—
4CR2	Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S…	electron microscopy	K	—	—
4CR2	Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S…	electron microscopy	K	—	—
4CR3	Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S…	electron microscopy	K	—	—
4CR3	Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S…	electron microscopy	K	—	—
4CR4	Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S…	electron microscopy	K	—	—
4CR4	Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S…	electron microscopy	K	—	—
5A5B	Structure of the 26S proteasome-Ubp6 complex	electron microscopy	K	—	—
5A5B	Structure of the 26S proteasome-UBP6 complex	electron microscopy	K	—	—
5MP9	26S proteasome in presence of ATP (s1)	electron microscopy	K	ATP, MG	—
5MP9	26S proteasome in presence of ATP (S1)	electron microscopy	K	ATP, MG	—
5MPA	26S proteasome in presence of ATP (s2)	electron microscopy	K	ATP, MG	4 (best 0.80)
5MPA	26S proteasome in presence of ATP (S2)	electron microscopy	K	ATP, MG	—
5MPB	26S proteasome in presence of AMP-PNP (s3)	electron microscopy	K	ANP, MG	5 (best 0.83)
5MPC	26S proteasome in presence of BeFx (s4)	electron microscopy	K	ADP, MG, ATP	—
5WVI	The resting state of yeast proteasome	electron microscopy	K	—	—
5WVK	Yeast proteasome-ADP-AlFx	electron microscopy	K	—	3 (best 0.82)
6EF0	Yeast 26S proteasome bound to ubiquitinated substrate (1D* motor state)	electron microscopy	K	ATP	6 (best 0.83)
6EF0	Yeast 26S proteasome bound to ubiquitinated substrate (1D* motor state)	electron microscopy	K	ATP	—
6EF1	Yeast 26S proteasome bound to ubiquitinated substrate (5D motor state)	electron microscopy	K	ATP	7 (best 0.90)
6EF1	Yeast 26S proteasome bound to ubiquitinated substrate (5D motor state)	electron microscopy	K	ATP	—
6EF2	Yeast 26S proteasome bound to ubiquitinated substrate (5T motor state)	electron microscopy	K	ATP, ADP	7 (best 0.81)
6EF2	Yeast 26S proteasome bound to ubiquitinated substrate (5T motor state)	electron microscopy	K	ATP, ADP	—
6EF3	Yeast 26S proteasome bound to ubiquitinated substrate (4D motor state)	electron microscopy	K	ATP, ADP	4 (best 0.83)
6EF3	Yeast 26S proteasome bound to ubiquitinated substrate (4D motor state)	electron microscopy	K	ADP	—
6FVT	26S proteasome, s1 state	electron microscopy	K	ATP, MG	—
6FVU	26S proteasome, s2 state	electron microscopy	K	ATP, MG	4 (best 0.86)
6FVV	26S proteasome, s3 state	electron microscopy	K	ATP, MG	5 (best 0.84)
6FVW	26S proteasome, s4 state	electron microscopy	K	ADP, MG, ATP	6 (best 0.83)
6FVX	26S proteasome, s5 state	electron microscopy	K	ATP, MG	7 (best 0.83)
6FVY	26S proteasome, s6 state	electron microscopy	K	ATP, MG	6 (best 0.81)
6J2C	Yeast proteasome in translocation competent state (C3-a)	electron microscopy	K	—	7 (best 0.85)
6J2N	yeast proteasome in substrate-processing state (C3-b)	electron microscopy	K	—	4 (best 0.81)
6J2X	Yeast proteasome in resting state (C1-a)	electron microscopy	K	—	—
7QO5	26S proteasome Rpt1-RK -Ubp6-UbVS complex in the si state	electron microscopy	K	ATP, MG	6 (best 0.83)
P33298	AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit 6B homolog (P33298)	predicted	A	—	3 (best 0.48)

Ligands

ATP · Adenosine-5'-triphosphate · in 19 records
MG · Magnesium ion · in 13 records
ADP · Adenosine-5'-diphosphate · in 6 records
ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record

Experiment against prediction

7QO5 chain K against the predicted model P33298: TM-score 0.94, RMSD 1.98 Å
5MPA chain K against the predicted model P33298: TM-score 0.94, RMSD 2.10 Å
5MPA chain K against the predicted model P33298: TM-score 0.94, RMSD 2.10 Å
6FVU chain K against the predicted model P33298: TM-score 0.94, RMSD 2.11 Å
5MP9 chain K against the predicted model P33298: TM-score 0.93, RMSD 2.28 Å
5MP9 chain K against the predicted model P33298: TM-score 0.93, RMSD 2.28 Å
6FVT chain K against the predicted model P33298: TM-score 0.93, RMSD 2.30 Å
6J2X chain K against the predicted model P33298: TM-score 0.93, RMSD 2.04 Å
6FVX chain K against the predicted model P33298: TM-score 0.92, RMSD 2.45 Å
2DZN chain D against the predicted model P33298: TM-score 0.92, RMSD 1.09 Å

Elsewhere

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