UniProt P33176

Kinesin-1 heavy chain (P33176)

Kinesin-1 heavy chain (UniProt P33176): 29 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 87 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P33176
Protein: Kinesin-1 heavy chain
Experimental structures: 29
Predicted models: 1
Ligands: 5
Pockets: 87 · 12 records with a druggable one

Structures

30 records of P33176 in the MolNFT archive: 29 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1BG2	Human ubiquitous kinesin motor domain	x-ray diffraction	A	—	—
1BG2	Human ubiquitous kinesin motor domain	x-ray diffraction	A	—	—
1MKJ	Human Kinesin Motor Domain With Docked Neck Linker	x-ray diffraction	A	—	—
1MKJ	Human kinesin motor domain with docked neck linker	x-ray diffraction	A	—	—
3J8X	High-resolution structure of no-nucleotide kinesin on microtubules	electron microscopy	K	—	—
3J8X	High-resolution structure of no-nucleotide kinesin on microtubules	electron microscopy	K	—	—
3J8Y	High-resolution structure of ATP analog-bound kinesin on microtubules	electron microscopy	K	—	—
3J8Y	High-resolution structure of ATP analog-bound kinesin on microtubules	electron microscopy	K	—	—
4HNA	Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN	x-ray diffraction	K	—	—
4HNA	Kinesin motor domain in the ADP-mg-alfx state in complex with tubulin and a darpin	x-ray diffraction	K	—	—
4LNU	Nucleotide-free kinesin motor domain in complex with tubulin and a DARPin	x-ray diffraction	K	—	—
4LNU	Nucleotide-free kinesin motor domain in complex with tubulin and a darpin	x-ray diffraction	K	—	—
5LT3	nucleotide-free kinesin-1 motor domain T87A mutant, P1 crystal form	x-ray diffraction	A, B, C, D, E, K	SO4	—
5LT3	Nucleotide-free kinesin-1 motor domain T87A mutant, P1 crystal form	x-ray diffraction	A, B, C, D, E, K	SO4	—
5LT4	nucleotide-free kinesin-1 motor domain T92V mutant, P1 crystal form	x-ray diffraction	A, B, C, D, E, K	SO4	20 (best 0.68)
5LT4	Nucleotide-free kinesin-1 motor domain T92V mutant, P1 crystal form	x-ray diffraction	A, B, C, D, E, K	SO4	—
6OJQ	Monomeric kinesin-1 motor domain in no-nucleotide state bound to GMPCPP-stabilized microtubule	electron microscopy	K	—	6 (best 0.82)
6OJQ	Monomeric kinesin-1 motor domain in no-nucleotide state bound to gmpcpp-stabilized microtubule	electron microscopy	K	—	—
7RIK	Magic-Angle-Spinning NMR Structure of Kinesin-1 Motor Domain Assembled with Microtubules	solid-state nmr	A	—	9 (best 0.59)
7TR1	CAKIP3[2-436]-L2-MUTANT(HSKHC) - AMP-pnp in complex with a microtubule	electron microscopy	K	MG, ANP	—
7TR2	Apo CAKIP3[2-436]-L2-MUTANT(HSKHC) in complex with a microtubule	electron microscopy	K	—	—
8IXD	GMPCPP-Alpha1C/Beta2A-microtubule decorated with kinesin non-seam region	electron microscopy	Y, S, T, U, V, W, X, Z, a	ATP	5 (best 0.82)
8IXE	GMPCPP-Alpha1C/Beta2A-microtubule decorated with kinesin seam region	electron microscopy	l, h, p, q	ATP	4 (best 0.82)
8IXF	GMPCPP-Alpha4A/Beta2A-microtubule decorated with kinesin non-seam region	electron microscopy	Y, S, T, U, V, W, X, Z, a	ATP	6 (best 0.83)
8RHB	Microtubule-associated kinesin-1 tail complex bound to AMPPNP, single-headed state	electron microscopy	K, T, t	ANP, MG	5 (best 0.82)
8RHH	Microtubule-associated kinesin-1 tail complex bound to AMPPNP, two-headed state	electron microscopy	K, L, T, t	ANP, MG	8 (best 0.81)
8RIK	Microtubule-associated kinesin-1 tail complex bound to ADP, single-headed state	electron microscopy	K, T, t	ADP	3 (best 0.79)
8RIZ	Microtubule-associated kinesin-1 tail complex bound to ADP, two-headed state	electron microscopy	K, L, T	ADP, MG	10 (best 0.80)
9GNQ	Microtubule-associated Kif5B IAK tail mutant bound to ADP	electron microscopy	K	ADP	5 (best 0.79)
P33176	AlphaFold monomer V2.0 prediction for kinesin-1 heavy chain (P33176)	predicted	A	—	6 (best 0.51)

Ligands

MG · Magnesium ion · in 4 records
SO4 · Sulfate ion · in 4 records
ADP · Adenosine-5'-diphosphate · in 3 records
ANP · Phosphoaminophosphonic acid-adenylate ester · in 3 records
ATP · Adenosine-5'-triphosphate · in 3 records

Experiment against prediction

8RIK chain T against the predicted model P33176: TM-score 1.00, RMSD 0.03 Å
8RIK chain t against the predicted model P33176: TM-score 0.99, RMSD 0.04 Å
8RHH chain L against the predicted model P33176: TM-score 0.97, RMSD 1.40 Å
1MKJ chain A against the predicted model P33176: TM-score 0.97, RMSD 1.60 Å
1MKJ chain A against the predicted model P33176: TM-score 0.97, RMSD 1.60 Å
8RIZ chain L against the predicted model P33176: TM-score 0.96, RMSD 1.46 Å
8RHB chain K against the predicted model P33176: TM-score 0.95, RMSD 1.69 Å
3J8Y chain K against the predicted model P33176: TM-score 0.95, RMSD 1.89 Å
3J8Y chain K against the predicted model P33176: TM-score 0.95, RMSD 1.89 Å
4HNA chain K against the predicted model P33176: TM-score 0.95, RMSD 1.94 Å

Elsewhere

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