UniProt P32754
4-hydroxyphenylpyruvate dioxygenase (P32754)
4-hydroxyphenylpyruvate dioxygenase (UniProt P32754), EC 1.13.11.27: 6 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 60 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P32754
- Protein
- 4-hydroxyphenylpyruvate dioxygenase
- EC
- 1.13.11.27
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 60 · 6 records with a druggable one
Structures
7 records of P32754 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3ISQ | Crystal structure of human 4-Hydroxyphenylpyruvate dioxygenase | x-ray diffraction | A | CO, CL, NA | 5 (best 0.76) |
| 3ISQ | Crystal structure of human 4-hydroxyphenylpyruvate dioxygenase | x-ray diffraction | A | CO, CL, NA | 5 (best 0.76) |
| 5EC3 | Structural insight into the catalyitc mechanism of human 4-Hydroxyphenylpyruvate dioxygenase | x-ray diffraction | A | CO | 5 (best 0.75) |
| 5EC3 | Structural insight into the catalyitc mechanism of human 4- hydroxyphenylpyruvate dioxygenase | x-ray diffraction | A | CO | 5 (best 0.75) |
| 8IM2 | Crystal structure of human HPPD complexed with NTBC | x-ray diffraction | A, B, C, D, E, F | CO, NTD | 20 (best 0.83) |
| 8IM3 | Crystal structure of human HPPD complexed with compound a10 | x-ray diffraction | A, B, C, D, E, F | CO, 92U | 20 (best 0.86) |
| P32754 | AlphaFold monomer V2.0 prediction for 4-hydroxyphenylpyruvate dioxygenase (P32754) | predicted | A | — | — |
Ligands
- CO · Cobalt (II) ion · in 6 records
- CL · Chloride ion · in 2 records
- NA · Sodium ion · in 2 records
- 92U · [1,3-diethyl-2,2-bis(oxidanylidene)-2$l^{6},1,3-benzothiadiazol-5-yl]-(1-methyl-5-oxidanyl-pyrazol-4-yl)methanone · in 1 record
- NTD · 2-{hydroxy[2-nitro-4-(trifluoromethyl) phenyl]methylene}cyclohexane-1,3-dione · in 1 record
Experiment against prediction
- 5EC3 chain A against the predicted model P32754: TM-score 0.99, RMSD 0.83 Å
- 5EC3 chain A against the predicted model P32754: TM-score 0.99, RMSD 0.83 Å
- 3ISQ chain A against the predicted model P32754: TM-score 0.99, RMSD 0.83 Å
- 3ISQ chain A against the predicted model P32754: TM-score 0.99, RMSD 0.83 Å
- 8IM2 chain D against the predicted model P32754: TM-score 0.96, RMSD 1.57 Å
- 8IM3 chain E against the predicted model P32754: TM-score 0.96, RMSD 1.77 Å
- 8IM2 chain C against the predicted model P32754: TM-score 0.96, RMSD 1.75 Å
- 8IM2 chain B against the predicted model P32754: TM-score 0.95, RMSD 1.77 Å
- 8IM3 chain D against the predicted model P32754: TM-score 0.95, RMSD 1.66 Å
- 8IM3 chain A against the predicted model P32754: TM-score 0.95, RMSD 1.70 Å
Elsewhere
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