UniProt P31785
Cytokine receptor common subunit gamma (P31785)
Cytokine receptor common subunit gamma (UniProt P31785): 20 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P31785
- Protein
- Cytokine receptor common subunit gamma
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 28 · 5 records with a druggable one
Structures
21 records of P31785 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2B5I | cytokine receptor complex | x-ray diffraction | C | — | — |
| 2B5I | Cytokine receptor complex | x-ray diffraction | C | — | — |
| 2ERJ | Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2 | x-ray diffraction | C, G | — | — |
| 2ERJ | Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2 | x-ray diffraction | C, G | — | — |
| 3BPL | Crystal structure of the IL4-IL4R-Common Gamma ternary complex | x-ray diffraction | C | — | — |
| 3BPL | Crystal structure of the IL4-IL4R-common gamma ternary complex | x-ray diffraction | C | — | — |
| 3QAZ | IL-2 mutant D10 ternary complex | x-ray diffraction | C, F, I, L, O, R, U, X, a, d, g, j | — | — |
| 3QAZ | Il-2 mutant D10 ternary complex | x-ray diffraction | C, F, I, L, O, R, U, X, a, d, g, j | — | — |
| 3QB7 | Interleukin-4 mutant RGA bound to cytokine receptor common gamma | x-ray diffraction | C, D | — | — |
| 3QB7 | Interleukin-4 mutant rga bound to cytokine receptor common gamma | x-ray diffraction | C, D | — | — |
| 4GS7 | Structure of the Interleukin-15 quaternary complex | x-ray diffraction | C | — | — |
| 4GS7 | Structure of the interleukin-15 quaternary complex | x-ray diffraction | C | — | — |
| 5M5E | Crystal structure of a interleukin-2 variant in complex with interleukin-2 receptor | x-ray diffraction | C | NAG, FUC, SO4 | 6 (best 0.56) |
| 5M5E | Crystal structure of a interleukin-2 variant in complex with interleukin-2 receptor | x-ray diffraction | C | NAG, SO4 | — |
| 6OEL | Engineered Fab bound to IL-4 receptor | x-ray diffraction | C | NAG | 6 (best 0.64) |
| 6OEL | Engineered Fab bound to il-4 receptor | x-ray diffraction | C | NAG | — |
| 7S2R | nanobody bound to IL-2Rg | x-ray diffraction | A | NAG, SO4 | 2 (best 0.60) |
| 7S2R | Nanobody bound to il-2RG | x-ray diffraction | A | NAG, SO4 | — |
| 8ENT | Interleukin-21 signaling complex with IL-21R and IL-2Rg | x-ray diffraction | C, F, I | NAG | 11 (best 0.65) |
| 9JQT | Structure of interleukin receptor common gamma chain (IL2Rgamma/CD132) in complex with 2D4 | electron microscopy | A | — | 3 (best 0.54) |
| P31785 | AlphaFold monomer V2.0 prediction for cytokine receptor common subunit gamma (P31785) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5M5E chain C against the predicted model P31785: TM-score 0.99, RMSD 0.46 Å
- 5M5E chain C against the predicted model P31785: TM-score 0.99, RMSD 0.46 Å
- 3QAZ chain C against the predicted model P31785: TM-score 0.99, RMSD 0.61 Å
- 3QAZ chain C against the predicted model P31785: TM-score 0.99, RMSD 0.61 Å
- 3QB7 chain C against the predicted model P31785: TM-score 0.98, RMSD 0.67 Å
- 3QB7 chain C against the predicted model P31785: TM-score 0.98, RMSD 0.67 Å
- 2ERJ chain C against the predicted model P31785: TM-score 0.98, RMSD 0.70 Å
- 2ERJ chain C against the predicted model P31785: TM-score 0.98, RMSD 0.70 Å
- 3QAZ chain F against the predicted model P31785: TM-score 0.98, RMSD 0.68 Å
- 3QAZ chain F against the predicted model P31785: TM-score 0.98, RMSD 0.68 Å
Elsewhere
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