UniProt P31644
Gamma-aminobutyric acid receptor subunit alpha-5 (P31644)
Gamma-aminobutyric acid receptor subunit alpha-5 (UniProt P31644): 17 experimental structures and 1 predicted model on GenesisL1, 18 ligands bound, 301 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P31644
- Protein
- Gamma-aminobutyric acid receptor subunit alpha-5
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 18
- Pockets
- 301 · 17 records with a druggable one
Structures
18 records of P31644 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5O8F | Structure of a chimaeric BETA3-ALPHA5 gabaa receptor in complex with nanobody NB25 and pregnanolone | x-ray diffraction | A, B, C, D, E | NAG, BMA, MAN, P9N | 20 (best 0.79) |
| 5OJM | Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 | x-ray diffraction | A, B, C, D, E | NAG, BMA, MAN | 20 (best 0.78) |
| 5OJM | Structure of a chimaeric BETA3-ALPHA5 gabaa receptor in complex with nanobody NB25 | x-ray diffraction | A, B, C, D, E | NAG, BMA, MAN | 20 (best 0.78) |
| 6A96 | Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25 | electron microscopy | A | NAG, ABU | 6 (best 0.84) |
| 6A96 | Cryo-EM structure of the human ALPHA5BETA3 gabaa receptor in complex with GABA and NB25 | electron microscopy | A | NAG, ABU | 6 (best 0.84) |
| 8BEJ | GABA-A receptor a5 homomer - a5V3 - APO | electron microscopy | A, B, C, D, E | NAG | 20 (best 0.78) |
| 8BGI | GABA-A receptor a5 homomer - a5V1 - Flumazenil | x-ray diffraction | A, B, C, D, E | SO4, FYP, P9N, NAG | 20 (best 0.78) |
| 8BHA | GABA-A receptor a5 homomer - a5V3 - Basmisanil - HR | electron microscopy | A, B, C, D, E | NAG, QI0 | 16 (best 0.84) |
| 8BHB | GABA-A receptor a5 homomer - a5V3 - RO154513 | electron microscopy | A, B, C, D, E | NAG, EIE | 19 (best 0.79) |
| 8BHG | GABA-A receptor a5 heteromer - a5V2 - Bretazenil | x-ray diffraction | A, C, D, E | QMU, NO3, NAG | 20 (best 0.79) |
| 8BHI | GABA-A receptor a5 homomer - a5V3 - RO5211223 | electron microscopy | A, B, C, D, E | NAG, QKF | 20 (best 0.79) |
| 8BHK | GABA-A receptor a5 homomer - a5V3 - Diazepam | electron microscopy | A, B, C, D, E | NAG, DZP | 20 (best 0.81) |
| 8BHM | GABA-A receptor a5 homomer - a5V3 - DMCM | electron microscopy | A, B, C, D, E | NAG, R63 | 20 (best 0.81) |
| 8BHO | GABA-A receptor a5 homomer - a5V3 - L655708 | electron microscopy | A, B, C, D, E | NAG, QMJ | 17 (best 0.81) |
| 8BHQ | GABA-A receptor a5 homomer - a5V3 - RO7172670 | electron microscopy | A, B, C, D, E | NAG, QR3 | 18 (best 0.81) |
| 8BHR | GABA-A receptor a5 homomer - a5V3 - RO7015738 | electron microscopy | A, B, C, D, E | NAG, QM7 | 19 (best 0.79) |
| 8BHS | GABA-A receptor a5 homomer - a5V3 - RO4938581 | electron microscopy | A, B, C, D, E | NAG, QK9 | 20 (best 0.79) |
| P31644 | AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit alpha-5 (P31644) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 17 records
- BMA · beta-D-mannopyranose · in 3 records
- MAN · alpha-D-mannopyranose · in 3 records
- ABU · Gamma-amino-butanoic acid · in 2 records
- P9N · Pregnanolone · in 2 records
- DZP · 7-chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one · in 1 record
- EIE · Ethyl 8-[(azanylidene-$L^{4}-azanylidene)amino]-5-methyl-6-oxidanylidene-4~{H}-imidazo[1,5-A][1, 4]benzodiazepine-3-carboxylate · in 1 record
- FYP · Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1, 5-a][1,4]benzodiazepine-3-carboxylate · in 1 record
- NO3 · Nitrate ion · in 1 record
- QI0 · Basmisanil · in 1 record
- QK9 · 5-[bis(fluoranyl)methyl]-15-bromanyl-2,4,8,9,11-pentazatetracyclo[11.4.0.0^{2,6}.0^{8,12}]heptadeca-1(13),3,5,9,11,14,16-heptaene · in 1 record
- QKF · [1,1-bis(oxidanylidene)-1,4-thiazinan-4-yl]-[6-[[5-methyl-3-(6-methylpyridin-3-yl)-1,2-oxazol-4-yl]methoxy]pyridin-3-yl]methanone · in 1 record
- QM7 · 6-[[5-methyl-3-(6-methylpyridin-3-yl)-1,2-oxazol-4-yl]methoxy]-~{N}-[(2~{S})-1-oxidanylpentan-2-yl]pyridine-3-carboxamide · in 1 record
- QMJ · ethyl (7~{S})-15-methoxy-12-oxidanylidene-2,4,11-triazatetracyclo[11.4.0.0^{2,6}.0^{7,11}]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate · in 1 record
- QMU · Bretazenil · in 1 record
- QR3 · 2-[[5-methyl-3-(6-methylpyridazin-3-yl)-1,2-oxazol-4-yl]methyl]-5-(5-oxa-2-azaspiro[3.5]nonan-2-yl)pyridazin-3-one · in 1 record
- R63 · methyl 4-ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylate · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 5O8F chain E against the predicted model P28472: TM-score 0.98, RMSD 1.09 Å
- 5O8F chain D against the predicted model P28472: TM-score 0.98, RMSD 1.09 Å
- 5O8F chain C against the predicted model P28472: TM-score 0.98, RMSD 1.09 Å
- 5O8F chain A against the predicted model P28472: TM-score 0.98, RMSD 1.11 Å
- 5O8F chain B against the predicted model P28472: TM-score 0.98, RMSD 1.12 Å
- 5OJM chain A against the predicted model P28472: TM-score 0.97, RMSD 1.21 Å
- 5OJM chain A against the predicted model P28472: TM-score 0.97, RMSD 1.21 Å
- 5OJM chain B against the predicted model P28472: TM-score 0.97, RMSD 1.22 Å
- 5OJM chain B against the predicted model P28472: TM-score 0.97, RMSD 1.22 Å
- 5OJM chain D against the predicted model P28472: TM-score 0.97, RMSD 1.22 Å
Elsewhere
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