UniProt P30531
Sodium- and chloride-dependent GABA transporter 1 (P30531)
Sodium- and chloride-dependent GABA transporter 1 (UniProt P30531): 4 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P30531
- Protein
- Sodium- and chloride-dependent GABA transporter 1
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 15 · 4 records with a druggable one
Structures
5 records of P30531 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7SK2 | Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation | electron microscopy | A | TGI | — |
| 7Y7V | Cryo-EM structure of human apo GABA transporter GAT1 in an inward-open state | electron microscopy | A | NAG, CL | 4 (best 0.79) |
| 7Y7W | Cryo-EM structure of human GABA transporter GAT1 bound with GABA in NaCl solution in an… | electron microscopy | A | ABU, NAG, NA, CL | 4 (best 0.74) |
| 7Y7Z | Cryo-EM structure of human GABA transporter GAT1 bound with tiagabine in NaCl solution in an… | electron microscopy | A | TGI, NAG, CL | 2 (best 0.78) |
| P30531 | AlphaFold monomer V2.0 prediction for sodium- and chloride-dependent GABA transporter 1 (P30531) | predicted | A | — | 5 (best 0.77) |
Ligands
Experiment against prediction
- 7Y7W chain A against the predicted model P30531: TM-score 0.94, RMSD 2.19 Å
- 7Y7Z chain A against the predicted model P30531: TM-score 0.90, RMSD 2.84 Å
- 7Y7V chain A against the predicted model P30531: TM-score 0.90, RMSD 2.85 Å
- 7SK2 chain A against the predicted model P30531: TM-score 0.89, RMSD 2.90 Å
Elsewhere
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