UniProt P29218
Inositol monophosphatase 1 (P29218)
Inositol monophosphatase 1 (UniProt P29218), EC 3.1.3.25, 3.1.3.94: 21 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P29218
- Protein
- Inositol monophosphatase 1
- EC
- 3.1.3.25, 3.1.3.94
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 8 · 1 record with a druggable one
Structures
22 records of P29218 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AWB | Human myo-inositol monophosphatase in complex with D-inositol-1-phosphate and calcium | x-ray diffraction | A, B | — | — |
| 1AWB | Human myo-inositol monophosphatase in complex with D-inositol-1- phosphate and calcium | x-ray diffraction | A, B | — | — |
| 1IMA | Structural analysis of inositol monophosphatase complexes with substrates | x-ray diffraction | A, B | — | — |
| 1IMA | Structural analysis of inositol monophosphatase complexes with substrates | x-ray diffraction | A, B | — | — |
| 1IMB | Structural analysis of inositol monophosphatase complexes with substrates | x-ray diffraction | A, B | — | — |
| 1IMB | Structural analysis of inositol monophosphatase complexes with substrates | x-ray diffraction | A, B | — | — |
| 1IMC | Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion… | x-ray diffraction | A, B | — | — |
| 1IMC | Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion… | x-ray diffraction | A, B | — | — |
| 1IMD | Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion… | x-ray diffraction | A, B | — | — |
| 1IMD | Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion… | x-ray diffraction | A, B | — | — |
| 1IME | Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion… | x-ray diffraction | A, B | — | — |
| 1IME | Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion… | x-ray diffraction | A, B | — | — |
| 1IMF | Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion… | x-ray diffraction | A | — | — |
| 1IMF | Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion… | x-ray diffraction | A | — | — |
| 2HHM | Structure of inositol monophosphatase, the putative target of lithium therapy | x-ray diffraction | A, B | — | — |
| 2HHM | Structure of inositol monophosphatase, the putative target of lithium therapy | x-ray diffraction | A, B | — | — |
| 4AS4 | Structure of human inositol monophosphatase 1 | x-ray diffraction | A, B | — | — |
| 4AS4 | Structure of human inositol monophosphatase 1 | x-ray diffraction | A, B | — | — |
| 6GIU | Human impase with L-690330 | x-ray diffraction | A, B | MN, L69 | — |
| 6GJ0 | Human impase with mn | x-ray diffraction | A, B | MN | — |
| 6ZK0 | 1.47A human IMPase with ebselen | x-ray diffraction | AAA, BBB | NA, MN, SO4, 9JT | 8 (best 0.77) |
| P29218 | AlphaFold monomer V2.0 prediction for inositol monophosphatase 1 (P29218) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4AS4 chain A against the predicted model P29218: TM-score 1.00, RMSD 0.34 Å
- 4AS4 chain A against the predicted model P29218: TM-score 1.00, RMSD 0.34 Å
- 6ZK0 chain AAA against the predicted model P29218: TM-score 1.00, RMSD 0.39 Å
- 6GJ0 chain A against the predicted model P29218: TM-score 1.00, RMSD 0.40 Å
- 6GJ0 chain B against the predicted model P29218: TM-score 1.00, RMSD 0.42 Å
- 1AWB chain A against the predicted model P29218: TM-score 1.00, RMSD 0.41 Å
- 1AWB chain A against the predicted model P29218: TM-score 1.00, RMSD 0.41 Å
- 1IMC chain B against the predicted model P29218: TM-score 1.00, RMSD 0.42 Å
- 1IMC chain B against the predicted model P29218: TM-score 1.00, RMSD 0.42 Å
- 1IME chain A against the predicted model P29218: TM-score 1.00, RMSD 0.42 Å
Elsewhere
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