UniProt P28773

Granulocyte-macrophage colony-stimulating factor (P28773)

Granulocyte-macrophage colony-stimulating factor (UniProt P28773): 4 experimental structures and 1 predicted model on GenesisL1, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P28773
Protein: Granulocyte-macrophage colony-stimulating factor
Experimental structures: 4
Predicted models: 1
Pockets: 9 · 1 record with a druggable one

Structures

5 records of P28773 in the MolNFT archive: 4 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
5D22	Structure of ovine granulocyte-macrophage colony-stimulating factor	x-ray diffraction	A, B	—	1 (best 0.32)
5D22	Structure of ovine granulocyte-macrophage colony-stimulating factor	x-ray diffraction	A, B	—	—
5D28	Complex of GM-CSF/IL-2 inhibition factor with Granulocyte-macrophage colony-stimulating factor	x-ray diffraction	B, C	—	8 (best 0.67)
5D28	Complex of gm-CSF/IL-2 inhibition factor with granulocyte-macrophage colony-stimulating factor	x-ray diffraction	B, C	—	—
P28773	AlphaFold monomer V2.0 prediction for granulocyte-macrophage colony- stimulating factor (P28773)	predicted	A	—	—

Experiment against prediction

5D28 chain B against the predicted model P28773: TM-score 0.99, RMSD 0.47 Å
5D28 chain B against the predicted model P28773: TM-score 0.99, RMSD 0.47 Å
5D22 chain B against the predicted model P28773: TM-score 0.98, RMSD 1.01 Å
5D22 chain B against the predicted model P28773: TM-score 0.98, RMSD 1.01 Å
5D22 chain A against the predicted model P28773: TM-score 0.97, RMSD 1.09 Å
5D22 chain A against the predicted model P28773: TM-score 0.97, RMSD 1.09 Å
5D28 chain C against the predicted model P28773: TM-score 0.91, RMSD 0.92 Å
5D28 chain C against the predicted model P28773: TM-score 0.91, RMSD 0.92 Å

Elsewhere

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