UniProt P28504
Hirudin-2 (P28504)
Hirudin-2 (UniProt P28504): 101 experimental structures on GenesisL1, 3 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P28504
- Protein
- Hirudin-2
- Experimental structures
- 101
- Predicted models
- 0
- Pockets
- 3 · 3 records with a druggable one
Structures
101 records of P28504 in the MolNFT archive: 101 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A3B | Complex of human alpha-thrombin with the bifunctional boronate inhibitor BOROLOG1 | x-ray diffraction | I | — | — |
| 1A3B | Complex of human alpha-thrombin with the bifunctional boronate inhibitor BOROLOG1 | x-ray diffraction | I | — | — |
| 1A3E | Complex of human alpha-thrombin with the bifunctional boronate inhibitor BOROLOG2 | x-ray diffraction | I | — | — |
| 1A3E | Complex of human alpha-thrombin with the bifunctional boronate inhibitor BOROLOG2 | x-ray diffraction | I | — | — |
| 1ABI | Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and… | x-ray diffraction | I | — | — |
| 1ABI | Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and… | x-ray diffraction | I | — | — |
| 1C1U | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | I | — | — |
| 1C1U | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | I | — | — |
| 1C1V | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | I | — | — |
| 1C1V | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | I | — | — |
| 1C1W | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | I | — | — |
| 1C1W | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | I | — | — |
| 1C4U | Selective non electrophilic thrombin inhibitors with cyclohexyl moieties. | x-ray diffraction | 3 | — | — |
| 1C4U | Selective non electrophilic thrombin inhibitors with cyclohexyl moieties. | x-ray diffraction | 3 | — | — |
| 1C5L | Structural basis for selectivity of a small molecule, S1-binding, sub-micromolar inhibitor of… | x-ray diffraction | I | — | — |
| 1C5L | Structural basis for selectivity of a small molecule, S1-binding, sub- micromolar inhibitor of… | x-ray diffraction | I | — | — |
| 1C5N | Structural basis for selectivity of a small molecule, S1-binding, sub-micromolar inhibitor of… | x-ray diffraction | I | — | — |
| 1C5N | Structural basis for selectivity of a small molecule, S1-binding, sub- micromolar inhibitor of… | x-ray diffraction | I | — | — |
| 1C5O | Structural basis for selectivity of a small molecule, S1-binding, sub-micromolar inhibitor of… | x-ray diffraction | I | — | — |
| 1C5O | Structural basis for selectivity of a small molecule, S1-binding, sub- micromolar inhibitor of… | x-ray diffraction | I | — | — |
| 1D9I | Structure of thrombin complexed with selective non-electophilic inhibitors having cyclohexyl… | x-ray diffraction | I | — | — |
| 1D9I | Structure of thrombin complexed with selective non-electophilic inhibitors having cyclohexyl… | x-ray diffraction | I | — | — |
| 1FPC | Active site mimetic inhibition of thrombin | x-ray diffraction | I | — | — |
| 1FPC | Active site mimetic inhibition of thrombin | x-ray diffraction | I | — | — |
| 1GHV | A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network… | x-ray diffraction | I | — | — |
| 1GHV | A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network… | x-ray diffraction | I | — | — |
| 1GHW | A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network… | x-ray diffraction | I | — | — |
| 1GHW | A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network… | x-ray diffraction | I | — | — |
| 1GHX | A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network… | x-ray diffraction | I | — | — |
| 1GHX | A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network… | x-ray diffraction | I | — | — |
| 1GHY | A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network… | x-ray diffraction | I | — | — |
| 1GHY | A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network… | x-ray diffraction | I | — | — |
| 1GJ4 | Selectivity at S1, H2O displacement, upa, tpa, SER190/ALA190 protease, structure-based drug design | x-ray diffraction | I | — | — |
| 1GJ4 | Selectivity at S1, H2O displacement, upa, tpa, SER190/ALA190 protease, structure-based drug design | x-ray diffraction | I | — | — |
| 1GJ5 | Selectivity at S1, H2O displacement, upa, tpa, SER190/ALA190 protease, structure-based drug design | x-ray diffraction | I | — | — |
| 1GJ5 | Selectivity at S1, H2O displacement, upa, tpa, SER190/ALA190 protease, structure-based drug design | x-ray diffraction | I | — | — |
| 1IHS | Crystal structure of the complex of human alpha-thrombin and non-hydrolyzable bifunctional… | x-ray diffraction | I | — | — |
| 1IHS | Crystal structure of the complex of human alpha-thrombin and non- hydrolyzable bifunctional… | x-ray diffraction | I | — | — |
| 1IHT | Crystal structure of the complex of human alpha-thrombin and non-hydrolyzable bifunctional… | x-ray diffraction | I | — | — |
| 1IHT | Crystal structure of the complex of human alpha-thrombin and non- hydrolyzable bifunctional… | x-ray diffraction | I | — | — |
| 1NM6 | thrombin in complex with selective macrocyclic inhibitor at 1.8A | x-ray diffraction | B | — | — |
| 1NM6 | Thrombin in complex with selective macrocyclic inhibitor at 1.8A | x-ray diffraction | B | — | — |
| 1NT1 | thrombin in complex with selective macrocyclic inhibitor | x-ray diffraction | H | — | — |
| 1NT1 | Thrombin in complex with selective macrocyclic inhibitor | x-ray diffraction | H | — | — |
| 1NY2 | Human alpha thrombin inhibited by RPPGF and hirugen | x-ray diffraction | 3 | — | — |
| 1NY2 | Human alpha thrombin inhibited by rppgf and hirugen | x-ray diffraction | 3 | — | — |
| 1O2G | Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine… | x-ray diffraction | I | — | — |
| 1O2G | Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine… | x-ray diffraction | I | — | — |
| 1QBV | Crystal structure of thrombin complexed with an guanidine-mimetic inhibitor | x-ray diffraction | E | — | — |
| 1QBV | Crystal structure of thrombin complexed with an guanidine-mimetic inhibitor | x-ray diffraction | E | — | — |
| 1SB1 | Novel Non-Covalent Thrombin Inhibitors Incorporating P1 4,5,6,7-Tetrahydrobenzothiazole Arginine… | x-ray diffraction | I | — | — |
| 1SB1 | Novel non-covalent thrombin inhibitors incorporating P1 4,5,6,7- tetrahydrobenzothiazole arginine… | x-ray diffraction | I | — | — |
| 1SL3 | crystal structue of Thrombin in complex with a potent P1 heterocycle-Aryl based inhibitor | x-ray diffraction | B | — | — |
| 1SL3 | Crystal structue of thrombin in complex with a potent P1 heterocycle- aryl based inhibitor | x-ray diffraction | B | — | — |
| 1TA2 | Crystal structure of thrombin in complex with compound 1 | x-ray diffraction | B | — | — |
| 1TA2 | Crystal structure of thrombin in complex with compound 1 | x-ray diffraction | B | — | — |
| 1TA6 | Crystal structure of thrombin in complex with compound 14b | x-ray diffraction | B | — | — |
| 1TA6 | Crystal structure of thrombin in complex with compound 14B | x-ray diffraction | B | — | — |
| 1TMT | Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to… | x-ray diffraction | J | — | — |
| 1TMT | Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to… | x-ray diffraction | J | — | — |
41 records more on the page itself.
Elsewhere
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