UniProt P28329
Choline O-acetyltransferase (P28329)
Choline O-acetyltransferase (UniProt P28329), EC 2.3.1.6: 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P28329
- Protein
- Choline O-acetyltransferase
- EC
- 2.3.1.6
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 6 · 1 record with a druggable one
Structures
11 records of P28329 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2FY2 | Structures of ligand bound human choline acetyltransferase provide insight into regulation of… | x-ray diffraction | A | — | — |
| 2FY2 | Structures of ligand bound human choline acetyltransferase provide insight into regulation of… | x-ray diffraction | A | — | — |
| 2FY3 | Structures of ligand bound human choline acetyltransferase provides insight into regulation of… | x-ray diffraction | A | — | — |
| 2FY3 | Structures of ligand bound human choline acetyltransferase provides insight into regulation of… | x-ray diffraction | A | — | — |
| 2FY4 | Structures of ligand bound human choline acetyltransferase provide insight into regulation of… | x-ray diffraction | A | — | — |
| 2FY4 | Structures of ligand bound human choline acetyltransferase provide insight into regulation of… | x-ray diffraction | A | — | — |
| 2FY5 | Structures of ligand bound human choline acetyltransferase provide insight into regulation of… | x-ray diffraction | A | — | — |
| 2FY5 | Structures of ligand bound human choline acetyltransferase provide insight into regulation of… | x-ray diffraction | A | — | — |
| 7AMD | In situ assembly of choline acetyltransferase ligands by a hydrothiolation reaction reveals key… | x-ray diffraction | A | RMW, NA | 6 (best 0.83) |
| 7AMD | In situ assembly of choline acetyltransferase ligands by a hydrothiolation reaction reveals key… | x-ray diffraction | A | RMW, NA | — |
| P28329 | AlphaFold monomer V2.0 prediction for choline O-acetyltransferase (P28329) | predicted | A | — | — |
Ligands
- NA · Sodium ion · in 2 records
- RMW · [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{R})-2,2-dimethyl-4-[[3-[2-[(1~{R})-2-(1-methylpyridin-4-yl)-1-naphthalen-1-yl-ethyl]sulfanylethylamino]-3-oxidanylidene-propyl]amino]-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate · in 2 records
Experiment against prediction
- 2FY5 chain A against the predicted model P28329: TM-score 1.00, RMSD 0.43 Å
- 2FY5 chain A against the predicted model P28329: TM-score 1.00, RMSD 0.43 Å
- 7AMD chain A against the predicted model P28329: TM-score 1.00, RMSD 0.47 Å
- 7AMD chain A against the predicted model P28329: TM-score 1.00, RMSD 0.47 Å
- 2FY4 chain A against the predicted model P28329: TM-score 1.00, RMSD 0.55 Å
- 2FY4 chain A against the predicted model P28329: TM-score 1.00, RMSD 0.55 Å
- 2FY3 chain A against the predicted model P28329: TM-score 1.00, RMSD 0.63 Å
- 2FY3 chain A against the predicted model P28329: TM-score 1.00, RMSD 0.63 Å
- 2FY2 chain A against the predicted model P28329: TM-score 0.99, RMSD 0.63 Å
- 2FY2 chain A against the predicted model P28329: TM-score 0.99, RMSD 0.63 Å
Elsewhere
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