UniProt P28327
Rhodopsin kinase GRK1 (P28327)
Rhodopsin kinase GRK1 (UniProt P28327), EC 2.7.11.14: 28 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P28327
- Protein
- Rhodopsin kinase GRK1
- EC
- 2.7.11.14
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 5 · 1 record with a druggable one
Structures
29 records of P28327 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2I94 | NMR Structure of recoverin bound to rhodopsin kinase | solution nmr | B | — | — |
| 2I94 | NMR structure of recoverin bound to rhodopsin kinase | solution nmr | B | — | — |
| 3C4W | Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.7A | x-ray diffraction | A, B | — | — |
| 3C4W | Crystal structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.7A | x-ray diffraction | A, B | — | — |
| 3C4X | Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.9A | x-ray diffraction | A, B | — | — |
| 3C4X | Crystal structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.9A | x-ray diffraction | A, B | — | — |
| 3C4Y | Crystal Structure of Apo form of G protein coupled receptor kinase 1 at 7.51A | x-ray diffraction | A, B | — | — |
| 3C4Y | Crystal structure of apo form of G protein coupled receptor kinase 1 at 7.51A | x-ray diffraction | A, B | — | — |
| 3C4Z | Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at… | x-ray diffraction | A | — | — |
| 3C4Z | Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at… | x-ray diffraction | A | — | — |
| 3C50 | Crystal Structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 2.6A | x-ray diffraction | A, B | — | — |
| 3C50 | Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 2.6A | x-ray diffraction | A, B | — | — |
| 3C51 | Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at… | x-ray diffraction | A, B | — | — |
| 3C51 | Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at… | x-ray diffraction | A, B | — | — |
| 3QC9 | Crystal structure of cross-linked bovine GRK1 T8C/N480C double mutant complexed with ADP and mg | x-ray diffraction | A, B, C, D | — | — |
| 3T8O | Rhodopsin kinase (GRK1) L166K mutant at 2.5A resolution | x-ray diffraction | A | — | — |
| 3T8O | Rhodopsin kinase (GRK1) L166K mutant at 2.5A resolution | x-ray diffraction | A | — | — |
| 4L9I | Bovine G Protein Coupled Receptor Kinase 1 in Complex with Paroxetine | x-ray diffraction | A, B | — | — |
| 4L9I | Bovine G protein coupled receptor kinase 1 in complex with paroxetine | x-ray diffraction | A, B | — | — |
| 4PNI | Bovine G protein-coupled receptor kinase 1 in complex with GSK2163632A | x-ray diffraction | A | — | — |
| 4PNI | Bovine G protein-coupled receptor kinase 1 in complex with GSK2163632A | x-ray diffraction | A | — | — |
| 4WBO | Bovine G Protein Coupled Receptor Kinase 1 in Complex with Amlexanox | x-ray diffraction | A, B, C, D | — | — |
| 4WBO | Bovine G protein coupled receptor kinase 1 in complex with amlexanox | x-ray diffraction | A, B, C, D | — | — |
| 7MT8 | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin | electron microscopy | G | SGV | 5 (best 0.86) |
| 7MT8 | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin | electron microscopy | G | SGV | — |
| 7MT9 | Rhodopsin kinase (GRK1) in complex with rhodopsin | electron microscopy | G | SGV | — |
| 7MTA | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and FAB1 | electron microscopy | G | SGV | — |
| 7MTB | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and FAB6 | electron microscopy | G | SGV | — |
| P28327 | AlphaFold monomer V2.0 prediction for rhodopsin kinase GRK1 (P28327) | predicted | A | — | — |
Ligands
- SGV · Sangivamycin · in 5 records
Experiment against prediction
- 3C4X chain B against the predicted model P28327: TM-score 0.99, RMSD 0.64 Å
- 3C4X chain B against the predicted model P28327: TM-score 0.99, RMSD 0.64 Å
- 3C50 chain A against the predicted model P28327: TM-score 0.99, RMSD 0.67 Å
- 3C50 chain A against the predicted model P28327: TM-score 0.99, RMSD 0.67 Å
- 3QC9 chain C against the predicted model P28327: TM-score 0.99, RMSD 0.72 Å
- 3QC9 chain B against the predicted model P28327: TM-score 0.99, RMSD 0.73 Å
- 3QC9 chain A against the predicted model P28327: TM-score 0.99, RMSD 0.73 Å
- 3C50 chain B against the predicted model P28327: TM-score 0.99, RMSD 0.80 Å
- 3C50 chain B against the predicted model P28327: TM-score 0.99, RMSD 0.80 Å
- 3C51 chain B against the predicted model P28327: TM-score 0.99, RMSD 0.79 Å
Elsewhere
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