UniProt P28065
Proteasome subunit beta type-9 (P28065)
Proteasome subunit beta type-9 (UniProt P28065), EC 3.4.25.1: 8 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P28065
- Protein
- Proteasome subunit beta type-9
- EC
- 3.4.25.1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 8 · 2 records with a druggable one
Structures
9 records of P28065 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6AVO | Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively… | electron microscopy | A, F | — | 4 (best 0.75) |
| 6AVO | Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively… | electron microscopy | A, F | — | — |
| 6E5B | Human Immunoproteasome 20S particle in complex with compound 1 | x-ray diffraction | N, b | HUJ, NA | — |
| 6E5B | Human immunoproteasome 20S particle in complex with compound 1 | x-ray diffraction | N, b | HUJ, NA | — |
| 7AWE | Human immunoproteasome 20S particle in complex with [(1R)-2-(1… | x-ray diffraction | H, V | S5K, NA | — |
| 7B12 | HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH… | x-ray diffraction | H, V | SKN | — |
| 7B12 | Human immunoproteasome 20S particle in complex with [2-(3… | x-ray diffraction | H, V | SKN | — |
| 9FST | Yeast 20S proteasome with human beta1i (1-51) in complex with epoxyketone inhibitor LU-001i | x-ray diffraction | N, b | A1IF8, SO4, MG | 3 (best 0.72) |
| P28065 | AlphaFold monomer V2.0 prediction for proteasome subunit beta type-9 (P28065) | predicted | A | — | 1 (best 0.32) |
Ligands
- NA · Sodium ion · in 3 records
- HUJ · [(1R)-3-methyl-1-[[1-[2-[(2,3,4-trimethoxyphenyl) carbonylamino]ethyl]-1,2,3-triazol-4-yl]carbonylamino]butyl]-tris(oxidanyl)boron · in 2 records
- SKN · ((R)-2-(3-ethylphenyl)-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)ethyl)boronic acid · in 2 records
- A1IF8 · azanylidene-[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(1S)-2-cyclohexyl-1-[(2R,3S,6R,7S)-3-methanoyl-2,6-dimethyl-6,7-bis(oxidanyl)-1,4-oxazepan-7-yl]ethyl]amino]-1-oxidanylidene-hexan-2-yl]carbamoyl]-4,4-bis(fluoranyl)pyrrolidin-1-yl]-1-oxidanylidene-propan-2-yl]amino]-2-oxidanylidene-ethyl]imino-azanium · in 1 record
- MG · Magnesium ion · in 1 record
- S5K · [(1R)-2-(1-benzofuran-3-yl)-1-{[(1S,2R,4R)-7-oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 9FST chain b against the predicted model P38624: TM-score 1.00, RMSD 0.33 Å
- 9FST chain N against the predicted model P38624: TM-score 1.00, RMSD 0.34 Å
- 6E5B chain N against the predicted model P28065: TM-score 0.99, RMSD 0.39 Å
- 6E5B chain N against the predicted model P28065: TM-score 0.99, RMSD 0.39 Å
- 7AWE chain H against the predicted model P28065: TM-score 0.99, RMSD 0.40 Å
- 7B12 chain H against the predicted model P28065: TM-score 0.99, RMSD 0.43 Å
- 7B12 chain H against the predicted model P28065: TM-score 0.99, RMSD 0.43 Å
- 6AVO chain A against the predicted model P28065: TM-score 0.99, RMSD 0.45 Å
- 6AVO chain A against the predicted model P28065: TM-score 0.99, RMSD 0.45 Å
- 9FST chain N against the predicted model P28065: TM-score 0.97, RMSD 0.90 Å
Elsewhere
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