UniProt P28062
Proteasome subunit beta type-8,Proteasome subunit beta type-5 (P28062)
Proteasome subunit beta type-8,Proteasome subunit beta type-5 (UniProt P28062), EC 3.4.25.1: 40 experimental structures on GenesisL1, 18 ligands bound, 39 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P28062
- Protein
- Proteasome subunit beta type-8,Proteasome subunit beta type-5
- EC
- 3.4.25.1
- Experimental structures
- 40
- Predicted models
- 0
- Ligands
- 18
- Pockets
- 39 · 9 records with a druggable one
Structures
40 records of P28062 in the MolNFT archive: 40 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5L5A | Yeast 20S proteasome with human BETA5I (1-138; R57T) | x-ray diffraction | K, Y | MG | — |
| 5L5B | Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) | x-ray diffraction | K, Y | MG | 5 (best 0.78) |
| 5L5B | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) | x-ray diffraction | K, Y | MG | — |
| 5L5D | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, 04C | — |
| 5L5E | Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, 3BV | — |
| 5L5E | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, 3BV | — |
| 5L5F | Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, BO2 | — |
| 5L5F | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, BO2 | — |
| 5L5H | Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, 39V | 5 (best 0.78) |
| 5L5H | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, 39V | — |
| 5L5I | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, 38X | — |
| 5L5J | Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, 6N5 | 4 (best 0.78) |
| 5L5J | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, 6N5 | — |
| 5L5O | Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, 79P | — |
| 5L5O | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, 79P | — |
| 5L5P | Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, 79L | — |
| 5L5P | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, 79L | — |
| 5L5Q | Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, 6NV | 4 (best 0.78) |
| 5L5Q | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, 6NV | — |
| 5L5R | Yeast 20S proteasome with human beta5i (1-138;V31M) and human beta6 (97-111; 118-133) | x-ray diffraction | K, Y | MG | 6 (best 0.78) |
| 5L5R | Yeast 20S proteasome with human BETA5I (1-138;V31M) and human BETA6 (97-111; 118-133) | x-ray diffraction | K, Y | MG | — |
| 5L5S | Yeast 20S proteasome with human beta5i (1-138; V31M) and human beta6 (97-111; 118-133) in complex… | x-ray diffraction | K, Y | MG, 39V | — |
| 5L5S | Yeast 20S proteasome with human BETA5I (1-138; V31M) and human BETA6 (97-111; 118-133) in complex… | x-ray diffraction | K, Y | MG, 39V | — |
| 5L5T | Yeast 20S proteasome with human beta5i (1-138; V31M) and human beta6 (97-111; 118-133) in complex… | x-ray diffraction | K, Y | MG, 79P | — |
| 5L5T | Yeast 20S proteasome with human BETA5I (1-138; V31M) and human BETA6 (97-111; 118-133) in complex… | x-ray diffraction | K, Y | MG, 79P | — |
| 5L5U | Yeast 20S proteasome with human beta5i (1-138; V31M) and human beta6 (97-111; 118-133) in complex… | x-ray diffraction | K, Y | MG, 04C | 3 (best 0.75) |
| 5L5U | Yeast 20S proteasome with human BETA5I (1-138; V31M) and human BETA6 (97-111; 118-133) in complex… | x-ray diffraction | K, Y | MG, 04C | — |
| 5L5V | 'yeast 20S proteasome with human BETA5I (1-138; V31M) and human BETA6 (97-111; 118-133) in complex… | x-ray diffraction | K, Y | MG, 6NV | — |
| 5LTT | Yeast 20S proteasome with human beta5i (1-138; R57T)in complex with PR-924 | x-ray diffraction | K, Y | MG, 39V | 4 (best 0.78) |
| 5LTT | Yeast 20S proteasome with human BETA5I (1-138; R57T)IN complex with pr-924 | x-ray diffraction | K, Y | 39V, MG | — |
| 5M2B | Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, 7DX | 3 (best 0.75) |
| 5M2B | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | K, Y | MG, 7DX | — |
| 6AVO | Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively… | electron microscopy | C, D | BZ7 | 5 (best 0.79) |
| 6AVO | Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively… | electron microscopy | C, D | — | — |
| 6E5B | Human Immunoproteasome 20S particle in complex with compound 1 | x-ray diffraction | K, Y | NA, HUJ, SCN | — |
| 6E5B | Human immunoproteasome 20S particle in complex with compound 1 | x-ray diffraction | K, Y | NA, HUJ, SCN | — |
| 7AWE | Human immunoproteasome 20S particle in complex with [(1R)-2-(1… | x-ray diffraction | L, Z | S5K, NA, SCN | — |
| 7B12 | HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH… | x-ray diffraction | L, Z | SO4, SKN, NA | — |
| 7B12 | Human immunoproteasome 20S particle in complex with [2-(3… | x-ray diffraction | L, Z | SO4, SKN, NA | — |
| P28062 | AlphaFold monomer V2.0 prediction for proteasome subunit beta type-8 (P28062) | — | — | — |
Ligands
- MG · Magnesium ion · in 32 records
- 39V · N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-N-[(2S, 4R)-5-hydroxy-4-methyl-3-oxo-1-phenylpentan-2-yl]-L-tryptophanamide · in 6 records
- NA · Sodium ion · in 5 records
- 79P · (2~{S})-3-(1~{H}-indol-3-yl)-~{N}-[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]-2-[[(2~{R})-2-(2-morpholin-4-ylethanoylamino) propanoyl]amino]propanamide · in 4 records
- 04C · 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol · in 3 records
- 6NV · ~{N}-[(2~{R})-1-[[(2~{S})-3-(4-methoxyphenyl)-1-[[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]amino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-methyl-5~{H}-indene-2-carboxamide · in 3 records
- SCN · Thiocyanate ion · in 3 records
- 3BV · N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-phenylalaninamide · in 2 records
- 6N5 · ~{N}-[(2~{S})-1-[[(2~{S})-3-(4-methoxyphenyl)-1-[[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]amino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-methyl-5~{H}-indene-2-carboxamide · in 2 records
- 79L · (2~{S})-3-(4-methoxyphenyl)-~{N}-[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]-2-[[(2~{R})-2-(2-morpholin-4-ylethanoylamino) propanoyl]amino]propanamide · in 2 records
- 7DX · (2~{S})-2-cyclohexyl-4-oxidanylidene-4-[[7-(4-phenyl-1, 3-thiazol-2-yl)quinolin-2-yl]amino]butanoic acid · in 2 records
- BO2 · N-[(1R)-1-(dihydroxyboryl)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide · in 2 records
- HUJ · [(1R)-3-methyl-1-[[1-[2-[(2,3,4-trimethoxyphenyl) carbonylamino]ethyl]-1,2,3-triazol-4-yl]carbonylamino]butyl]-tris(oxidanyl)boron · in 2 records
- SKN · ((R)-2-(3-ethylphenyl)-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)ethyl)boronic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- 38X · N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-N-[(2S, 4R)-1-cyclohexyl-5-hydroxy-4-methyl-3-oxopentan-2-yl]-L-tryptophanamide · in 1 record
- BZ7 · N~1~-{2-[([1,1'-biphenyl]-3-carbonyl)amino]ethyl}-N~4~-tert-butyl-N~2~-(3-phenylpropanoyl)-L-aspartamide · in 1 record
- S5K · [(1R)-2-(1-benzofuran-3-yl)-1-{[(1S,2R,4R)-7-oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.