UniProt P27915
RNA-directed RNA polymerase NS5 (P27915)
RNA-directed RNA polymerase NS5 (UniProt P27915), EC 2.1.1.56, 2.1.1.57: 21 experimental structures on GenesisL1, 12 ligands bound, 33 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P27915
- Protein
- RNA-directed RNA polymerase NS5
- EC
- 2.1.1.56, 2.1.1.57, 2.7.7.48, 3.4.21.91, 3.6.1.15, 3.6.4.13
- Experimental structures
- 21
- Predicted models
- 0
- Ligands
- 12
- Pockets
- 33 · 4 records with a druggable one
Structures
21 records of P27915 in the MolNFT archive: 21 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1UZG | Crystal structure of the dengue type 3 virus envelope protein | x-ray diffraction | A, B | — | — |
| 1UZG | Crystal structure of the dengue type 3 virus envelope protein | x-ray diffraction | A, B | — | — |
| 3VTT | High Resolution crystal structure of Dengue 3 Envelope protein domain III (ED3) | x-ray diffraction | A, B | — | — |
| 3VTT | High resolution crystal structure of dengue 3 envelope protein domain III (ED3) | x-ray diffraction | A, B | — | — |
| 5CCV | Crystal structure of full-length NS5 from dengue virus type 3 | x-ray diffraction | A, B, C, D, E, F, G, H | ZN, SAH | 20 (best 0.87) |
| 5CCV | Crystal structure of full-length NS5 from dengue virus type 3 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5E9Q | Dengue 3 NS5 methyltransferase bound to S-adenosyl methionine and molecule BF174 | x-ray diffraction | A, C | SAM, 5KY | 4 (best 0.68) |
| 5E9Q | Dengue 3 NS5 methyltransferase bound to S-adenosyl methionine and molecule BF174 | x-ray diffraction | A, C | — | — |
| 5EC8 | Dengue 3 NS5 methyltransferase bound to S-adenosyl methionine and compound BF175 | x-ray diffraction | A, C | 5LP | — |
| 5EC8 | Dengue 3 NS5 methyltransferase bound to S-adenosyl methionine and compound BF175 | x-ray diffraction | A, C | — | — |
| 5EHG | Dengue 3 NS5 methyltransferase bound to S-adenosyl methionine and molecule BF341 | x-ray diffraction | A, C | SAM, 5O0 | 5 (best 0.68) |
| 5EHG | Dengue 3 NS5 methyltransferase bound to S-adenosyl methionine and molecule BF341 | x-ray diffraction | A, C | — | — |
| 5EHI | Dengue 3 NS5 methyltransferase bound to S-adenosyl methionine and molecule BF287 | x-ray diffraction | A, C | SAM, 5O3 | 4 (best 0.67) |
| 5EHI | Dengue 3 NS5 methyltransferase bound to S-adenosyl methionine and molecule BF287 | x-ray diffraction | A, C | — | — |
| 5EIF | Dengue 3 NS5 methyltransferase bound to S-adenosyl methionine and fragment NB2C3 | x-ray diffraction | A, C | 4M0 | — |
| 5EIF | Dengue 3 NS5 methyltransferase bound to S-adenosyl methionine and fragment NB2C3 | x-ray diffraction | A, C | — | — |
| 5EIW | Dengue 3 NS5 methyltransferase bound to S-adenosyl methionine and fragment NB3C2 | x-ray diffraction | A, C | X0V | — |
| 5EIW | Dengue 3 NS5 methyltransferase bound to S-adenosyl methionine and fragment NB3C2 | x-ray diffraction | A, C | — | — |
| 5EKX | Dengue 3 NS5 methyltransferase bound to S-adenosylmethionine and fragment NB2E11 | x-ray diffraction | A, B | 2CQ | — |
| 5EKX | Dengue 3 NS5 methyltransferase bound to S-adenosylmethionine and fragment NB2E11 | x-ray diffraction | A, B | — | — |
| 7A3S | Crystal structure of dengue 3 virus envelope glycoprotein | x-ray diffraction | A, B, C | SO4, NAG | — |
Ligands
- SAM · S-adenosylmethionine · in 3 records
- 2CQ · 4-chloro-5-methylbenzene-1,2-diamine · in 1 record
- 4M0 · 2-azanyl-4-methyl-benzoic acid · in 1 record
- 5KY · 2-({[2-amino-4-(trifluoromethyl)phenyl]carbamoyl}amino)-4-methylbenzoic acid · in 1 record
- 5LP · 2-[(2-azanyl-4-chloranyl-phenyl)carbamoylamino]-4-methyl-benzoic acid · in 1 record
- 5O0 · 4-[3-[(2-azanyl-4-chloranyl-phenyl)carbamoylamino]phenyl]sulfonyloxybenzoic acid · in 1 record
- 5O3 · 4-[[3-[(2-azanyl-4-chloranyl-phenyl)carbamoylamino]phenyl]sulfonylamino]benzoic acid · in 1 record
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 1 record
- SAH · S-adenosyl-L-homocysteine · in 1 record
- SO4 · Sulfate ion · in 1 record
- X0V · 4-(trifluoromethyl)benzene-1,2-diamine · in 1 record
- ZN · Zinc ion · in 1 record
Elsewhere
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