UniProt P27815
Camp-specific 3',5'-cyclic phosphodiesterase 4A (P27815)
Camp-specific 3',5'-cyclic phosphodiesterase 4A (UniProt P27815): 8 experimental structures and 1 predicted model on GenesisL1, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P27815
- Protein
- Camp-specific 3',5'-cyclic phosphodiesterase 4A
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 8 · 1 record with a druggable one
Structures
9 records of P27815 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3HC8 | Investigation of Aminopyridiopyrazi s as PDE5 Inhibitors: Evaluation of Modifications to the… | x-ray diffraction | A | — | — |
| 3HC8 | Investigation of aminopyridiopyrazinones as PDE5 inhibitors: evaluation of modifications to the… | x-ray diffraction | A | — | — |
| 3HDZ | Identification, Synthesis, and SAR of Amino Substituted Pyrido[3,2b]pryaziones as Potent and… | x-ray diffraction | A | — | — |
| 3HDZ | Identification, synthesis, and sar of amino substituted PYRIDO[3, 2B]PRYAZIONES as potent and… | x-ray diffraction | A | — | — |
| 3I8V | Crystal structure of human PDE4a with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone | x-ray diffraction | A, B | — | — |
| 3I8V | Crystal structure of human PDE4A with 4-(3-butoxy-4-methoxyphenyl) methyl-2-imidazolidone | x-ray diffraction | A, B | — | — |
| 3TVX | The structure of PDE4A with pentoxifylline at 2.84A resolution | x-ray diffraction | A, B | — | — |
| 3TVX | The structure of PDE4A with pentoxifylline at 2.84A resolution | x-ray diffraction | A, B | — | — |
| P27815 | AlphaFold monomer V2.0 prediction for camp-specific 3',5'-cyclic phosphodiesterase 4A (P27815) | predicted | A | — | 8 (best 0.81) |
Experiment against prediction
- 3TVX chain A against the predicted model P27815: TM-score 0.99, RMSD 0.48 Å
- 3TVX chain A against the predicted model P27815: TM-score 0.99, RMSD 0.48 Å
- 3I8V chain B against the predicted model P27815: TM-score 0.99, RMSD 0.49 Å
- 3I8V chain B against the predicted model P27815: TM-score 0.99, RMSD 0.49 Å
- 3I8V chain A against the predicted model P27815: TM-score 0.99, RMSD 0.56 Å
- 3I8V chain A against the predicted model P27815: TM-score 0.99, RMSD 0.56 Å
- 3HC8 chain A against the predicted model O76074: TM-score 0.99, RMSD 0.53 Å
- 3HC8 chain A against the predicted model O76074: TM-score 0.99, RMSD 0.53 Å
- 3HDZ chain A against the predicted model O76074: TM-score 0.99, RMSD 0.59 Å
- 3HDZ chain A against the predicted model O76074: TM-score 0.99, RMSD 0.59 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.