UniProt P27037
Activin receptor type-2A (P27037)
Activin receptor type-2A (UniProt P27037), EC 2.7.11.30: 10 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P27037
- Protein
- Activin receptor type-2A
- EC
- 2.7.11.30
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 18 · 2 records with a druggable one
Structures
11 records of P27037 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3Q4T | Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin | x-ray diffraction | A, B | — | — |
| 3Q4T | Crystal structure of activin receptor type-iia (ACVR2A) kinase domain in complex with dorsomorphin | x-ray diffraction | A, B | — | — |
| 3SOC | Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin | x-ray diffraction | A, B | — | — |
| 3SOC | Crystal structure of activin receptor type-iia (ACVR2A) kinase domain in complex with a quinazolin | x-ray diffraction | A, B | — | — |
| 4ASX | Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with… | x-ray diffraction | A, B | — | — |
| 4ASX | Crystal structure of activin receptor type-iia (ACVR2A) kinase domain in complex with… | x-ray diffraction | A, B | — | — |
| 5NH3 | CRYSTAL STRUCTURE OF THE Activin receptor type-2A LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB… | x-ray diffraction | A, B | NAG | 6 (best 0.60) |
| 5NH3 | Crystal structure of the activin receptor type-2A ligand binding domain in complex with bimagrumab… | x-ray diffraction | A, B | NAG | — |
| 7U5P | Crystal structure of the activin receptor type-2A ligand binding domain in complex with activin-a | x-ray diffraction | A, C, E, G | NAG | 12 (best 0.51) |
| 7U5P | Crystal structure of the activin receptor type-2A ligand binding domain in complex with activin-a | x-ray diffraction | A, C, E, G | NAG | — |
| P27037 | AlphaFold monomer V2.0 prediction for activin receptor type-2A (P27037) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
Experiment against prediction
- 4ASX chain B against the predicted model P27037: TM-score 0.96, RMSD 1.63 Å
- 4ASX chain B against the predicted model P27037: TM-score 0.96, RMSD 1.63 Å
- 3Q4T chain A against the predicted model P27037: TM-score 0.96, RMSD 1.62 Å
- 3Q4T chain A against the predicted model P27037: TM-score 0.96, RMSD 1.62 Å
- 3SOC chain A against the predicted model P27037: TM-score 0.96, RMSD 1.67 Å
- 3SOC chain A against the predicted model P27037: TM-score 0.96, RMSD 1.67 Å
- 7U5P chain G against the predicted model P27037: TM-score 0.95, RMSD 0.99 Å
- 7U5P chain G against the predicted model P27037: TM-score 0.95, RMSD 0.99 Å
- 7U5P chain E against the predicted model P27037: TM-score 0.95, RMSD 0.97 Å
- 7U5P chain E against the predicted model P27037: TM-score 0.95, RMSD 0.97 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.