UniProt P26664
Non-structural protein 4A, Serine protease NS3 (P26664)
Non-structural protein 4A, Serine protease NS3 (UniProt P26664), EC 2.7.7.48, 3.4.21.98: 10 experimental structures on GenesisL1, 4 ligands bound, 1 pocket. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P26664
- Protein
- Non-structural protein 4A, Serine protease NS3
- EC
- 2.7.7.48, 3.4.21.98, 3.4.22.-, 3.6.1.15, 3.6.4.13
- Experimental structures
- 10
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 1 · 0 records with a druggable one
Structures
10 records of P26664 in the MolNFT archive: 10 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6P6L | HCV NS3/4A protease domain of genotype 1A in complex with glecaprevir | x-ray diffraction | A | SO4, ZN, O31 | — |
| 6P6M | HCV NS3/4A protease domain of genotype 1A C159 in complex with glecaprevir | x-ray diffraction | A | O31, ZN, SO4, CL | — |
| 6P6O | HCV NS3/4A protease domain of genotype 1A D168E in complex with glecaprevir | x-ray diffraction | A | ZN, O31, SO4, CL | — |
| 6P6Q | HCV NS3/4A protease domain of genotype 1A3A chimera in complex with grazoprevir | x-ray diffraction | A, B | ZN, SO4 | — |
| 6P6R | HCV NS3/4A protease domain of genotype 1A3A chimera in complex with glecaprevir | x-ray diffraction | A | ZN, SO4, O31, CL | — |
| 6VDL | HCV NS3/4A protease A156T mutant in complex with glecaprevir | x-ray diffraction | A | ZN, O31, SO4 | — |
| 6VDL | HCV NS3/4A protease A156T mutant in complex with glecaprevir | x-ray diffraction | A | ZN, O31, SO4 | — |
| 6VDM | HCV NS3/4A protease A156T, D168E double mutant in complex with glecaprevir | x-ray diffraction | A | ZN, O31, SO4 | — |
| 6VDN | HCV NS3/4A protease A156T mutant | x-ray diffraction | A | ZN, SO4 | 1 (best 0.38) |
| 6VDN | HCV NS3/4A protease A156T mutant | x-ray diffraction | A | ZN, SO4 | — |
Ligands
- SO4 · Sulfate ion · in 10 records
- ZN · Zinc ion · in 10 records
- O31 · (3ar,7s,10s,12r,21e,24ar)-7-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl) sulfonyl]carbamoyl}cyclopropyl]-20,20-difluoro-5,8-dioxo-2,3,3A,5,6,7,8,11,12,20,23,24A-dodecahydro-1H, 10H-9,12-methanocyclopenta[18,19][1,10,17,3, 6]trioxadiazacyclononadecino[11,12-b]quinoxaline-10-carboxamide · in 7 records
- CL · Chloride ion · in 3 records
Elsewhere
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