UniProt P26446
Poly [ADP-ribose] polymerase 1 (P26446)
Poly [ADP-ribose] polymerase 1 (UniProt P26446), EC 2.4.2.30: 18 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P26446
- Protein
- Poly [ADP-ribose] polymerase 1
- EC
- 2.4.2.30
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 17 · 3 records with a druggable one
Structures
19 records of P26446 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A26 | The catalytic fragment of POLY(ADP-ribose) polymerase complexed with carba-NAD | x-ray diffraction | A | — | — |
| 1A26 | The catalytic fragment of POLY(ADP-ribose) polymerase complexed with carba-NAD | x-ray diffraction | A | — | — |
| 1EFY | Crystal structure of the catalytic fragment of poly (ADP-ribose) polymerase complexed with a… | x-ray diffraction | A | — | — |
| 1EFY | Crystal structure of the catalytic fragment of poly (ADP-ribose) polymerase complexed with a… | x-ray diffraction | A | — | — |
| 1PAX | The catalytic fragment of POLY(ADP-ribose) polymerase complexed with… | x-ray diffraction | A | — | — |
| 1PAX | The catalytic fragment of POLY(ADP-ribose) polymerase complexed with… | x-ray diffraction | A | — | — |
| 2PAW | The catalytic fragment of POLY(ADP-ribose) polymerase | x-ray diffraction | A | — | — |
| 2PAW | The catalytic fragment of POLY(ADP-ribose) polymerase | x-ray diffraction | A | — | — |
| 2PAX | The catalytic fragment of POLY(ADP-ribose) polymerase complexed with 4-amino-1,8-naphthalimide | x-ray diffraction | A | — | — |
| 2PAX | The catalytic fragment of POLY(ADP-ribose) polymerase complexed with 4-amino-1,8-naphthalimide | x-ray diffraction | A | — | — |
| 3PAX | The catalytic fragment of POLY(ADP-ribose) polymerase complexed with 3-methoxybenzamide | x-ray diffraction | A | — | — |
| 3PAX | The catalytic fragment of POLY(ADP-ribose) polymerase complexed with 3-methoxybenzamide | x-ray diffraction | A | — | — |
| 4PAX | The catalytic fragment of POLY(ADP-ribose) polymerase complexed with… | x-ray diffraction | A | — | — |
| 4PAX | The catalytic fragment of POLY(ADP-ribose) polymerase complexed with… | x-ray diffraction | A | — | — |
| 6I8M | The catalytic fragment of POLY(ADP-ribose) polymerase complexed with isoindolinone inhibitor | x-ray diffraction | A | H7W | 4 (best 0.76) |
| 6I8M | The catalytic fragment of POLY(ADP-ribose) polymerase complexed with isoindolinone inhibitor | x-ray diffraction | A | H7W | — |
| 6I8T | The catalytic fragment of POLY(ADP-ribose) polymerase complexed with an isoindolinone inhibitor | x-ray diffraction | A | H7Z | 4 (best 0.76) |
| 6I8T | The catalytic fragment of POLY(ADP-ribose) polymerase complexed with an isoindolinone inhibitor | x-ray diffraction | A | H7Z | — |
| P26446 | AlphaFold monomer V2.0 prediction for poly [ADP-ribose] polymerase 1 (P26446) | predicted | A | — | 9 (best 0.80) |
Ligands
Experiment against prediction
- 3PAX chain A against the predicted model P26446: TM-score 0.99, RMSD 0.85 Å
- 3PAX chain A against the predicted model P26446: TM-score 0.99, RMSD 0.85 Å
- 2PAX chain A against the predicted model P26446: TM-score 0.99, RMSD 0.86 Å
- 2PAX chain A against the predicted model P26446: TM-score 0.99, RMSD 0.86 Å
- 1PAX chain A against the predicted model P26446: TM-score 0.99, RMSD 0.86 Å
- 1PAX chain A against the predicted model P26446: TM-score 0.99, RMSD 0.86 Å
- 4PAX chain A against the predicted model P26446: TM-score 0.99, RMSD 0.86 Å
- 4PAX chain A against the predicted model P26446: TM-score 0.99, RMSD 0.86 Å
- 1A26 chain A against the predicted model P26446: TM-score 0.99, RMSD 0.87 Å
- 1A26 chain A against the predicted model P26446: TM-score 0.99, RMSD 0.87 Å
Elsewhere
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