UniProt P25929
Neuropeptide Y receptor type 1 (P25929)
Neuropeptide Y receptor type 1 (UniProt P25929), EC 3.2.1.17: 7 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P25929
- Protein
- Neuropeptide Y receptor type 1
- EC
- 3.2.1.17
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 26 · 4 records with a druggable one
Structures
8 records of P25929 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ZBH | The Crystal Structure of Human Neuropeptide Y Y1 Receptor with BMS-193885 | x-ray diffraction | A | 9AF | 5 (best 0.83) |
| 5ZBH | The crystal structure of human neuropeptide Y Y1 receptor with bms- 193885 | x-ray diffraction | A | 9AF | — |
| 5ZBQ | The Crystal Structure of human neuropeptide Y Y1 receptor with UR-MK299 | x-ray diffraction | A | 9AO | 9 (best 0.87) |
| 5ZBQ | The crystal structure of human neuropeptide Y Y1 receptor with ur- MK299 | x-ray diffraction | A | 9AO | — |
| 7VGX | Neuropeptide Y Y1 receptor (NPY1R) in complex with G protein and its endogeneous peptide-agonist… | electron microscopy | R | — | — |
| 7X9A | Cryo-EM structure of neuropeptide Y Y1 receptor in complex with npy and gi | electron microscopy | R | — | — |
| 8K6M | Structural complex of neuropeptide Y receptor 1 | electron microscopy | D | — | 7 (best 0.74) |
| P25929 | AlphaFold monomer V2.0 prediction for neuropeptide Y receptor type 1 (P25929) | predicted | A | — | 5 (best 0.80) |
Ligands
- 9AF · dimethyl 4-{3-[({3-[4-(3-methoxyphenyl)piperidin-1-yl]propyl}carbamoyl)amino]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate · in 2 records
- 9AO · N~2~-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-N~5~-(N'-{[2-(propanoylamino) ethyl]carbamoyl}carbamimidoyl)-D-ornithinamide · in 2 records
Experiment against prediction
- 7VGX chain R against the predicted model P25929: TM-score 0.92, RMSD 2.17 Å
- 8K6M chain D against the predicted model P25929: TM-score 0.90, RMSD 2.37 Å
- 7X9A chain R against the predicted model P25929: TM-score 0.90, RMSD 2.64 Å
- 5ZBH chain A against the predicted model P25929: TM-score 0.63, RMSD 2.24 Å
- 5ZBH chain A against the predicted model P25929: TM-score 0.63, RMSD 2.24 Å
- 5ZBQ chain A against the predicted model P25929: TM-score 0.59, RMSD 2.01 Å
- 5ZBQ chain A against the predicted model P25929: TM-score 0.59, RMSD 2.01 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.