UniProt P25205
DNA replication licensing factor MCM3 (P25205)
DNA replication licensing factor MCM3 (UniProt P25205), EC 3.6.4.12: 13 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 75 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P25205
- Protein
- DNA replication licensing factor MCM3
- EC
- 3.6.4.12
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 75 · 11 records with a druggable one
Structures
14 records of P25205 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6XTX | CryoEM structure of human CMG bound to ATPgammaS and DNA | electron microscopy | 3 | ADP, AGS, MG | 6 (best 0.83) |
| 6XTX | Cryoem structure of human cmg bound to atpgammas and DNA | electron microscopy | 3 | ADP, AGS, MG | — |
| 6XTY | Cryoem structure of human cmg bound to and-1 (cmga) | electron microscopy | 3 | — | — |
| 7PLO | H. sapiens replisome-CUL2/LRR1 complex | electron microscopy | 3 | ANP, MG | 4 (best 0.86) |
| 8S09 | H. sapiens MCM2-7 double hexamer bound to double stranded DNA | electron microscopy | 3, B | ADP, MG | 9 (best 0.89) |
| 8S0A | H. sapiens MCM2-7 hexamer bound to double stranded DNA | electron microscopy | 3 | ADP, MG | 8 (best 0.85) |
| 8S0B | H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex | electron microscopy | 3 | ADP, MG, AGS | 8 (best 0.84) |
| 8S0D | H. sapiens MCM bound to double stranded DNA and ORC1-6 | electron microscopy | 3 | ADP, MG, AGS | 6 (best 0.83) |
| 8S0E | H. sapiens OCCM bound to double stranded DNA | electron microscopy | 3 | — | 3 (best 0.81) |
| 8S0F | H. sapiens OC1M bound to double stranded DNA | electron microscopy | 3 | — | 2 (best 0.85) |
| 8W0E | Cryo-EM structure of a human MCM2-7 single hexamer on dsDNA | electron microscopy | 3 | MG, ADP | 9 (best 0.88) |
| 8W0F | Cryo-EM structure of a human MCM2-7 double hexamer on dsDNA | electron microscopy | 3, B | MG, ADP | 12 (best 0.88) |
| 8W0I | Cryo-EM structure of the human MCM2-7 heterohexamer | electron microscopy | 3 | MG, ADP, ATP | 8 (best 0.87) |
| P25205 | AlphaFold monomer V2.0 prediction for DNA replication licensing factor MCM3 (P25205) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8S0F chain 3 against the predicted model P25205: TM-score 0.96, RMSD 1.56 Å
- 7PLO chain 3 against the predicted model P25205: TM-score 0.90, RMSD 3.08 Å
- 8S0E chain 3 against the predicted model P25205: TM-score 0.81, RMSD 1.98 Å
- 8S0D chain 3 against the predicted model P25205: TM-score 0.81, RMSD 4.50 Å
- 8S0B chain 3 against the predicted model P25205: TM-score 0.81, RMSD 4.50 Å
- 8W0E chain 3 against the predicted model P25205: TM-score 0.81, RMSD 4.59 Å
- 8S0A chain 3 against the predicted model P25205: TM-score 0.80, RMSD 4.65 Å
- 8W0F chain 3 against the predicted model P25205: TM-score 0.79, RMSD 4.90 Å
- 8S09 chain 3 against the predicted model P25205: TM-score 0.79, RMSD 4.83 Å
- 8S09 chain B against the predicted model P25205: TM-score 0.79, RMSD 4.83 Å
Elsewhere
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